Results 161 to 170 of about 259,719 (301)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Protein loops are major contributors to DNA strand separation and high-fidelity substrate recognition for DNA methyltransferase CcrM. [PDF]

J Biol Chem
Konttinen O, Dangerfield T, Vargas J, Johnson KA, Reich N.   +4 more
europepmc   +1 more source

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

Chemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas, Laurent Le Corre, Mélanie Ethève‐Quelquejeu, Emmanuelle Braud   +3 more
wiley   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors. [PDF]

Int J Cancer
Wenger V, Garcia-Manero G, Zeiser R, Lübbert M.   +3 more
europepmc   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Role of non-coding RNAs in O⁶-methylguanine-DNA methyltransferase-positive glioblastoma (Review). [PDF]

Oncol Lett
Guo Y, Guo J, Xiao W, Lu Y.
europepmc   +1 more source

DNA Methyltransferases [PDF]

, 2011
openaire   +1 more source

DNA methyltransferase 1 correlates with immune modulation in pancreatic neuroendocrine tumors. [PDF]

Sci Rep
Saleh Z, Nation RJ, Moccia MC, Kalola A, Ghanem Y, Joshi H, Joneja U, Li Y, Spitz F, Gao T, Hong YK.   +10 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Altered DNA Methyltransferase Expression in Pulmonary Large-Cell Neuroendocrine Carcinoma: Pilot Experimental Data Targeted DNMT1, DNMT3A, and DNMT3B. [PDF]

Cancer Rep (Hoboken)
Put A, Trtkova KS, Mittak M, Herentinova P, Vaculova J, Cernekova R, Skarda J.   +6 more
europepmc   +1 more source