Results 181 to 190 of about 2,516,689 (307)

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Hansen Rs, C. Wijmenga, P. Luo, A. Stanek, T. Canfield, C. Weemaes, S. Gartler   +6 more
semanticscholar   +1 more source

Correction: miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1. [PDF]

Cell Death Dis
Xie HF, Liu YZ, Du R, Wang B, Chen MT, Zhang YY, Deng ZL, Li J.   +7 more
europepmc   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.

Journal of Medicinal Chemistry, 2014
Shijie Chen, Yulan Wang, Wen Zhou, Shanshan Li, Jianlong Peng, Zhe Shi, Junchi Hu, Yu-Chih Liu, H. Ding, Yijyun Lin, Linjuan Li, Su Cheng, Jingqiu Liu, T. Lu, Hualiang Jiang, Bo Liu, M. Zheng, C. Luo   +17 more
semanticscholar   +1 more source

Novel Strategies for Improved Treatment of O6-Methylguanine-DNA Methyltransferase Promoter-Methylated Glioma. [PDF]

Med Res Arch
Vasquez JC, Bindra RS, Gueble SE.
europepmc   +1 more source

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

The ESRP1 promoter reporter can function as an in vivo sensor of DNA methyltransferase inhibition. [PDF]

BMC Biotechnol
Lin L, Chen L, Jing Y, Chen Z.
europepmc   +1 more source

An accessible microfluidic perfusion platform for time‐restricted control of zebrafish embryonic patterning

Developmental Dynamics, EarlyView.
Abstract Understanding the dynamic nature of developmental networks requires live imaging techniques capable of capturing real‐time developmental processes in wild‐type and mutant embryos as they are exposed to pharmacological perturbations. A peculiar developmental patterning process in early vertebrate embryos is the sequential segmentation of ...
Mohammed Nakhuda, M. Fethullah Simsek
wiley   +1 more source

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.

Proceedings of the National Academy of Sciences of the United States of America, 1994
Ruth Juttermann, E. Li, R. Jaenisch
semanticscholar   +1 more source

DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development. [PDF]

Commun Biol
Ai K, Wu Y, Liang G, Kong H, Yang X, Li N, Liu Z, Dong Y, Xu J, Zhang L, Chen X, Fu Y, Wang L, Li L.   +13 more
europepmc   +1 more source