Results 91 to 100 of about 141,545 (201)

The transcriptional regulation of maspin : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand [PDF]

, 2004
Maspin (mammary serine protease inhibitor) is a tumour suppressing member of the serpin superfamily. Maspin is expressed in normal breast and prostate cells, but reportedly down regulated during progression of cancer in these tissues.
Hollings, Andrew
core  

Historical expectations with DNA methyltransferase inhibitor monotherapy in MDS: when is combination therapy truly "promising"? [PDF]

Blood Adv, 2022
Brunner AM, Fell G, Steensma DP.
europepmc   +1 more source

HIV Infection as an Independent Factor Accelerating Epigenetic Ageing in Men Treated with Integrase Inhibitors: A Case–Control Study

Viruses
A number of published studies suggest that HIV infection accelerates epigenetic ageing. The main aim of this study was to ascertain if HIV infection is an independent factor leading to DNA hypomethylation and accelerating epigenetic ageing in men ...
Mateusz Bożejko, Małgorzata Małodobra-Mazur, Andrzej Gnatowski, Monika Ołdakowska, Aleksandra Szymczak, Bartosz Szetela, Hubert Ciepłucha, Aleksander Zińczuk, Brygida Knysz   +8 more
doaj   +1 more source

Induced Production of New Diterpenoids in the Fungus

Natural Product Communications, 2014
The supplementation of a DNA methyltransferase inhibitor, 5-azacytidine (5-AZ), to the culture medium of Penicillium funiculosum , dramatically altered its metabolic profiles.
Dong-Ze Liu, Bo-Wen Liang, Xiao-Fei Li, Qiang Liu   +3 more
doaj   +1 more source

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence

Nature Communications
Bacteria have evolved a broad range of systems that provide defence against their viral predators, bacteriophages. Bacteriophage Exclusion (BREX) systems recognise and methylate 6 bp non-palindromic motifs within the host genome, and prevent replication ...
Sam C. Went, David M. Picton, Richard D. Morgan, Andrew Nelson, Aisling Brady, Giuseppina Mariano, David T. F. Dryden, Darren L. Smith, Nicolas Wenner, Jay C. D. Hinton, Tim R. Blower   +10 more
doaj   +1 more source

The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. [PDF]

, 2019
T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically.
Anderson, Mark S, Cortez, Jessica T, Eckalbar, Walter L, Erle, David J, Sin, Jun Hyung, Waterfield, Michael R, Zuckerman, Cassandra   +6 more
core  

Phase I Clinical Trial of DNA Methyltransferase Inhibitor Decitabine and PARP Inhibitor Talazoparib Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia. [PDF]

Clin Cancer Res, 2022
Baer MR, Kogan AA, Bentzen SM, Mi T, Lapidus RG, Duong VH, Emadi A, Niyongere S, O'Connell CL, Youngblood BA, Baylin SB, Rassool FV.   +11 more
europepmc   +1 more source

The O6-methyguanine-DNA methyltransferase inhibitor O6-benzylguanine enhanced activity of temozolomide + irinotecan against models of high-risk neuroblastoma. [PDF]

Anticancer Drugs, 2021
Hindle A, Koneru B, Makena MR, Lopez-Barcons L, Chen WH, Nguyen TH, Reynolds CP.   +6 more
europepmc   +1 more source

Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer

Scientific Reports
Proteasome is an essential organelle responsible for maintaining cellular protein homeostasis, but its relationship with DNA methylation remains unknown. In this study, we assessed DNA methylation of colorectal cancer (CRC) cells following treatment with
Wenwen Zhou, Yuling Sheng, Dingxue Hu, Yunyun An, Mengqi Yang, Wanqiu Wang, Shiva Basnet, Jingyu Yan, Shuxia Zhang, Qi Liu, Yunze Li, Yi Tan, Jing Gao, Kun Sun, Changzheng Du   +14 more
doaj   +1 more source

Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE). [PDF]

Clin Cancer Res, 2021
Crabb SJ, Danson S, Catto JWF, Hussain S, Chan D, Dunkley D, Downs N, Marwood E, Day L, Saunders G, Light M, Whitehead A, Ellis D, Sarwar N, Enting D, Birtle A, Johnson B, Huddart R, Griffiths G.   +18 more
europepmc   +1 more source