Results 81 to 90 of about 141,545 (201)

HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes [PDF]

, 2018
Skeletal muscle exhibits a high regenerative capacity, mainly due to the ability of satellite cells to replicate and differentiate in response to appropriate stimuli. Epigenetic control is effective at different stages of this process.
Adamo, Sergio, Bertin, Marco, Bianchi, Marzia, Consalvi, Silvia, De Bardi, Marco, Marroncelli, Nicoletta, Moresi, Viviana, Palacios, Daniela, Puri Pier, Lorenzo, Saccone, Valentina   +9 more
core   +2 more sources

Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet

Neurobiology of Disease, 2015
Quality nutrition during the period of brain formation is a predictor of brain functional capacity and plasticity during adulthood; however it is not clear how this conferred plasticity imparts long-term neural resilience.
Ethika Tyagi, Yumei Zhuang, Rahul Agrawal, Zhe Ying, Fernando Gomez-Pinilla   +4 more
doaj   +1 more source

Checkpoint inhibitor blockade and epigenetic reprogrammability in CD8 T-cell activation and exhaustion

Therapeutic Advances in Vaccines and Immunotherapy, 2020
CD8 + T-cell exhaustion is a dysfunctional state that is regulated through the expression of inhibitory checkpoint receptor genes including the cytotoxic T-lymphocyte–associated antigen 4, programmed death 1, and DNA methylation of effector genes ...
José Belizário, Maria Fernanda Destro Rodrigues   +1 more
doaj   +1 more source

Correction: Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases

PLOS ONE, 2016
[This corrects the article DOI: 10.1371/journal.pone.0162956.].
Rajnee Kanwal, Manish Datt, Xiaoqi Liu, Sanjay Gupta   +3 more
openaire   +3 more sources

Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis

Drug Design, Development and Therapy, 2017
Nan Zhang,* Yanyang Liu,* Yuyi Wang, Maoyuan Zhao, Li Tu, Feng Luo Department of Medical Oncology, Cancer Center, Lung Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s ...
Zhang N, Liu Y, Wang Y, Zhao M, Tu L, Luo F   +5 more
doaj  

Loci specific epigenetic drug sensitivity. [PDF]

, 2020
Therapeutic targeting of epigenetic modulators offers a novel approach to the treatment of multiple diseases. The cellular consequences of chemical compounds that target epigenetic regulators (epi-drugs) are complex.
Pilko, Anna, Wollman, Roy, Zhang, Thanutra   +2 more
core   +1 more source

Core Promoters of Pig SOD2 Gene and Its Expression Regulation by DNA Methylation

Veterinary Sciences
In pig production, oxidative stress in the placentas of pregnant sows is one of the most important factors affecting reproductive performance. Superoxide dismutase SOD2 is a critical component of the antioxidant system and determines the antioxidant ...
Minjun Zhao, Zhaoqi Pang, Chunhui Jia, Shunran Zhao, Wei Xia, Junjie Li, Chenyu Tao   +6 more
doaj   +1 more source

Retracted: DNA Methyltransferase Inhibitor 5-AZA-DC Regulates TGFβ1-Mediated Alteration of Neuroglial Cell Functions after Oxidative Stress. [PDF]

Oxid Med Cell Longev, 2023
Longevity OMAC.
europepmc   +1 more source

Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation

Scientific Reports
DNA methylation is an epigenetic mechanism that introduces a methyl group at the C5 position of cytosine. This reaction is catalyzed by DNA methyltransferases (DNMTs) and is essential for the regulation of gene transcription.
Genki Kudo, Takumi Hirao, Ryuhei Harada, Takatsugu Hirokawa, Yasuteru Shigeta, Ryunosuke Yoshino   +5 more
doaj   +1 more source

DNA methyltransferase inhibitor 5-azacytidine enhances neuroblastoma cell lysis by an oncolytic parainfluenza virus. [PDF]

Anticancer Drugs, 2023
Kedarinath K, Shiffer EM, Parks GD.
europepmc   +1 more source