Results 1 to 10 of about 71,628 (244)

Action-At-A-Distance in DNA Mismatch Repair: Mechanistic Insights and Models for How DNA and Repair Proteins Facilitate Long-Range Communication [PDF]

Biomolecules
Many DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these sites,
Bryce W. Collingwood, Scott J. Witte, Carol M. Manhart   +2 more
doaj   +2 more sources

The GHKL ATPase Family as a Paradigm for MutL Homolog Function in DNA Mismatch Repair. [PDF]

Int J Mol Sci
Piscitelli JM, Manhart CM.
europepmc   +3 more sources

ATP-Dependent Mismatch Recognition in DNA Replication Mismatch Repair

Quantum Reports, 2023
Mismatch repair is a critical step in DNA replication that occurs after base selection and proofreading, significantly increasing fidelity. However, the mechanism of mismatch recognition has not been established for any repair enzyme.
Nianqin Zhang, Yongjun Zhang
doaj   +1 more source

Review of the application of dMMR and microsatellite instability in the diagnosis and treatment of endometrial cancer

Annals of Oncology Research and Therapy, 2021
Mismatch repair genes are responsible for discovering and repairing base mismatches during DNA replication in cells. Defects in mismatch repair function will lead to accumulation of gene mutations, microsatellite instability, and ultimately tumorigenesis.
Guangjie Liao, Jingqiu Yang, Xinke Zhang
doaj   +1 more source

RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stability. [PDF]

Nucleic Acids Res
Provasek VE, Bacolla A, Rangaswamy S, Kodavati M, Mitra J, Yusuf IO, Malojirao VH, Vasquez V, Britz GW, Li GM, Xu Z, Mitra S, Garruto RM, Tainer JA, Hegde ML.   +14 more
europepmc   +3 more sources

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Nature Communications, 2022
Prime Editing is a versatile genome engineering tool. Here, the authors identify the DNA repair pathway known as mismatch repair as inhibitory for Prime Editing, thus, loss of mismatch repair enhances the efficiency of Prime Editing.
J. Ferreira da Silva, G. P. Oliveira, E. A. Arasa-Verge, C. Kagiou, A. Moretton, G. Timelthaler, J. Jiricny, J. I. Loizou   +7 more
doaj   +1 more source

The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions

Cells, 2021
Trinucleotide repeats are a peculiar class of microsatellites whose expansions are responsible for approximately 30 human neurological or developmental disorders.
Guy-Franck Richard
doaj   +1 more source

Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein

Frontiers in Microbiology, 2021
DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions.
Almaz Nigatu Tesfahun, Marina Alexeeva, Miglė Tomkuvienė, Aysha Arshad, Prashanna Guragain, Arne Klungland, Arne Klungland, Saulius Klimašauskas, Peter Ruoff, Svein Bjelland, Svein Bjelland   +10 more
doaj   +1 more source

Strand asymmetry influences mismatch resolution during a single-strand annealing

Genome Biology, 2022
Background Biases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are still poorly understood because it is difficult to isolate the contributions of DNA repair from those ...
Victoria O. Pokusaeva, Aránzazu Rosado Diez, Lorena Espinar, Albert Torelló Pérez, Guillaume J. Filion   +4 more
doaj   +1 more source

Immune Checkpoint Inhibitors in Tumors Harboring Homologous Recombination Deficiency: Challenges in Attaining Efficacy

Frontiers in Immunology, 2022
Cancer cells harbor genomic instability due to accumulated DNA damage, one of the cancer hallmarks. At least five major DNA Damage Repair (DDR) pathways are recognized to repair DNA damages during different stages of the cell cycle, comprehending base ...
Saulo Brito Silva, Carlos Wagner S. Wanderley, Leandro Machado Colli   +2 more
doaj   +1 more source