Results 1 to 10 of about 297,565 (330)

High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast [PDF]

eLife, 2017
In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Yi Yin, Margaret Dominska, Eunice Yim, Thomas D Petes   +3 more
doaj   +5 more sources

Vaccines for immunoprevention of DNA mismatch repair deficient cancers. [PDF]

J Immunother Cancer, 2022
The development of cancer vaccines to induce tumor-antigen specific immune responses was sparked by the identification of antigens specific to or overexpressed in cancer cells. However, weak immunogenicity and the mutational heterogeneity in many cancers
Hernandez-Sanchez A, Grossman M, Yeung K, Sei SS, Lipkin S, Kloor M.   +5 more
europepmc   +2 more sources

Action-At-A-Distance in DNA Mismatch Repair: Mechanistic Insights and Models for How DNA and Repair Proteins Facilitate Long-Range Communication [PDF]

Biomolecules
Many DNA metabolic pathways, including DNA repair, require the transmission of signals across long stretches of DNA or between DNA molecules. Solutions to this signaling challenge involve various mechanisms: protein factors can travel between these sites,
Bryce W. Collingwood, Scott J. Witte, Carol M. Manhart   +2 more
doaj   +2 more sources

DNA mismatch repair system regulates the expression of PD-L1 through DNMTs in cervical cancer. [PDF]

Cancer Cell Int
Guo F, Lu R, Kong W, Anwar M, Feng Y.
europepmc   +3 more sources

Pathogenic Insights into DNA Mismatch Repair (MMR) Genes-Proteins and Microsatellite Instability: Focus on Adrenocortical Carcinoma and Beyond. [PDF]

Diagnostics (Basel), 2023
Carsote M, Turturea IF, Turturea MR, Valea A, Nistor C, Gheorghisan-Galateanu AA.   +5 more
europepmc   +3 more sources

ATP-Dependent Mismatch Recognition in DNA Replication Mismatch Repair

Quantum Reports, 2023
Mismatch repair is a critical step in DNA replication that occurs after base selection and proofreading, significantly increasing fidelity. However, the mechanism of mismatch recognition has not been established for any repair enzyme.
Nianqin Zhang, Yongjun Zhang
doaj   +1 more source

Review of the application of dMMR and microsatellite instability in the diagnosis and treatment of endometrial cancer

Annals of Oncology Research and Therapy, 2021
Mismatch repair genes are responsible for discovering and repairing base mismatches during DNA replication in cells. Defects in mismatch repair function will lead to accumulation of gene mutations, microsatellite instability, and ultimately tumorigenesis.
Guangjie Liao, Jingqiu Yang, Xinke Zhang
doaj   +1 more source

MSH2, MSH6, MLH1, and PMS2 immunohistochemistry as highly sensitive screening method for DNA mismatch repair deficiency syndromes in pediatric high-grade glioma. [PDF]

Acta Neuropathol
Friker LL, Perwein T, Waha A, Dörner E, Klein R, Blattner-Johnson M, Layer JP, Sturm D, Nussbaumer G, Kwiecien R, Spier I, Aretz S, Kerl K, Hennewig U, Rohde M, Karow A, Bluemcke I, Schmitz AK, Reinhard H, Hernáiz Driever P, Wendt S, Weiser A, Guerreiro Stücklin AS, Gerber NU, von Bueren AO, Khurana C, Jorch N, Wiese M, Kratz CP, Eyrich M, Karremann M, Herrlinger U, Hölzel M, Jones DTW, Hoffmann M, Pietsch T, Gielen GH, Kramm CM.   +37 more
europepmc   +2 more sources

The role of DNA mismatch repair in immunotherapy of human cancer

International Journal on Biological Sciences, 2022
DNA mismatch repair (MMR) is an important pathway which helps to maintain genomic stability. Mutations in DNA MMR genes are found to promote cancer initiation and foster tumor progression.
Yuchen He, Luyuan Zhang, Ruoyu Zhou, Yumin Wang, Hao Chen   +4 more
semanticscholar   +1 more source

DNA Mismatch Repair and its Role in Huntington’s Disease

Journal of Huntington's Disease, 2021
DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects DNA replication errors, limits chromosomal rearrangements, and mediates the cellular response to many types of DNA damage.
R. Iyer, A. Pluciennik
semanticscholar   +1 more source