Results 121 to 130 of about 297,565 (330)

One‐Step Covalent Biofunctionalization of Tubular Constructs Enabled by Surface‐Embedded Radicals

Advanced Materials Technologies, EarlyView.
Uniform covalent biofunctionalization of tubular constructs is achieved in one step using surface‐embedded radicals generated by a novel plasma immersion ion implantation (PIII) technology. This scalable, solvent‐free technology advances bioengineered tubes for tissue engineering and implant applications.
Anyu Zhang, Katazhyna Redzikultsava, Leila Mamizadeh, Bingyan Liu, Jiayan Shao, Junyi Qian, Ziyu Wang, Angus Grant, Shih‐Liang Lee, Richard Tan, Marcela Bilek, Steven G. Wise, Behnam Akhavan   +12 more
wiley   +1 more source

The Influence of the Supporting Substrate on Single‐Particle Circular Differential Scattering of DNA Assembled Nanorod Dimers

Advanced Optical Materials, EarlyView.
For most microscopy measurements the sample is placed on a substrate, which causes symmetry breaking, especially relevant for chiral plasmonic nanostructures. DNA origami mediated X‐shaped AuNR dimers showing high structural purity in solution, exhibit significant diversity in lineshapes and signal intensities for their circular differential scattering
Amrita Chakraborty, Ojasvi Verma, Gopal Narmada Naidu, Mihir Dass, Zhenyang Jia, Christy F. Landes, Alessandro Alabastri, Peter Nordlander, Tim Liedl, Stephan Link   +9 more
wiley   +1 more source

DNA mismatch repair network gene polymorphism as a susceptibility factor for pancreatic cancer [PDF]

, 2011
Xiaoqun Dong, Yanan Li, Ping Chang, Kenneth R. Hess, James L. Abbruzzese, Donghui Li   +5 more
openalex   +1 more source

Toward Enhancing Chiro‐Optical and Magneto‐Optical Properties of Magnetic Nanocrystals by Surface Plasmons

Advanced Optical Materials, EarlyView.
Here, recent progress is highlighted in colloidal magnetoplasmonic hybrid nanomaterials, with a focus on chiral plasmonics. Metal nanocrystals with intrinsic chiroptical features can lead to a combination of chiral plasmonics and magneto‐optics effects when interacting with the magnetic counterpart, offering a foundation for systematically designing ...
Miguel Comesaña‐Hermo, Eloi Haltz, Alessio Gabbani, Francesco Pineider, Verónica Salgueiriño   +4 more
wiley   +1 more source

Histone Deacetylase 10 Regulates DNA Mismatch Repair and May Involve the Deacetylation of MutS Homolog 2*

Journal of Biological Chemistry, 2015
Background: The DNA mismatch repair protein MutS homolog 2 (MSH2) is an acetylated protein. Results: Histone deacetylase 10 (HDAC10) interacts with MSH2 and deacetylates MSH2 at Lys-73, which might stimulate MSH2 activity. Conclusion: HDAC10 promotes DNA
R. Radhakrishnan, Yixuan Li, Shengyan Xiang, F. Yuan, Zhigang Yuan, Elphine Telles, Jia Fang, D. Coppola, D. Shibata, William Arbuthnot Sir Lane, Yanbin Zhang, X. Zhang, E. Seto   +12 more
semanticscholar   +1 more source

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

Advanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka, Lenka Vaňková, Josef Sýkora, Věra Křížková, Jan Schwarz, Petr Bouř   +5 more
wiley   +1 more source

DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1 [PDF]

, 2010
Sarah A. Martin, Nuala McCabe, Michelle J Mullarkey, Robert Cummins, Darren J. Burgess, Yusaku Nakabeppu, Sugako Oka, Elaine W. Kay, Christopher J. Lord, Alan Ashworth   +9 more
openalex   +1 more source

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

Advanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song, Xiaoya Zou, Di Ma, Yuying Zhao, Tingting Liu, Bibiao Shen, Oumei Cheng   +6 more
wiley   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

Nature Communications
Cytosine base editors enable programmable and efficient genome editing using an intermediate featuring a U•G mismatch across from a DNA nick. This intermediate facilitates two major outcomes, C•G to T•A and C•G to G•C point mutations, and it is not ...
Sifeng Gu, Zsolt Bodai, Rachel A. Anderson, Hei Yu Annika So, Quinn T. Cowan, Alexis C. Komor   +5 more
doaj   +1 more source