Results 171 to 180 of about 71,628 (244)

The Evolutionarily Conserved Zinc Finger Motif in the Largest Subunit of Human Replication Protein A Is Required for DNA Replication and Mismatch Repair but Not for Nucleotide Excision Repair [PDF]

, 1998
Yi‐Ling Lin, Mahmud K. K. Shivji, Clark Chen, Richard D. Kolodner, Richard D. Wood, Anindya Dutta   +5 more
openalex   +1 more source

Mechanisms of Resistance to Cancer Immunotherapy: A Host–Tumor Interaction Perspective; A Review Article

Cancer Nexus, EarlyView.
Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa, Hamid Noori, Abdelkareem A. Ahmed   +2 more
wiley   +1 more source

Molecular and immune determinants of response in locally advanced deficient DNA mismatch repair/microsatellite instability-high gastric or gastroesophageal junction adenocarcinoma treated with neoadjuvant chemoimmunotherapy. [PDF]

Cell Commun Signal
Yu P, Huang X, Chen X, Chen H, Wang S, Wang D, Yan J, Chen J, Wei Q, Wu Z, Fang S, Chen H, Wang H, Zhu C, Huang L, Du Y, Bao H, Cheng X.   +17 more
europepmc   +1 more source

Precision unleashed: tackling DNA mismatch repair for enhanced prime editing. [PDF]

Mol Ther Nucleic Acids, 2023
Ramchandani R, Bharucha N, Karakikes I.
europepmc   +1 more source

Untangling DNA Mismatch Repair Complexes with smFRET and Tethered Particle Motion Analysis [PDF]

, 2019
Pengyu Hao, Sharonda LeBlanc, Dorothy A. Erie, Keith Weninger   +3 more
openalex   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Real-World Impact of Metformin on Outcomes in Patients with Deficient DNA Mismatch Repair and Microsatellite Instability (dMMR/MSI) Colorectal Cancer Treated with Immune Checkpoint Inhibitors. [PDF]

Cancers (Basel)
Gupta G, Sadeghipour N, Bicer F, Elliott A, Hinton A, Lou E, Vanderwalde AM, Ozluk AA, Khushman MM, Malla M, Outlaw D, Hussaini SQ, El-Rayes BF, Akce M.   +13 more
europepmc   +1 more source

The associated contributions of p53 and the DNA mismatch repair protein Msh6 to spontaneous tumorigenesis [PDF]

, 2007
Leah C. Young, Angela M. Keuling, Raymond Lai, Patrick N. Nation, Victor A. Tron, Susan E. Andrew   +5 more
openalex   +1 more source

Whole tissue imaging of cellular boundaries at sub‐micron resolutions for deep learning cell segmentation: Applications in the analysis of epithelial bending of ectoderm

Developmental Dynamics, EarlyView.
Abstract Background To understand cellular morphology, biologists have relied on traditional optical microscopy of tissues combined with tissue clearing protocols to image structures deep within tissues. Unfortunately, these protocols often struggle to retain cell boundary markers, especially at high enough resolutions necessary for precise cell ...
Sam C. P. Norris, Jimmy K. Hu, Neil H. Shubin   +2 more
wiley   +1 more source

Comparison of clinicopathological parameters with the presence of Epstein-Barr virus and the absence of DNA mismatch repair proteins in gastric adenocarcinomas. [PDF]

Asian Biomed (Res Rev News)
Eyeoğlu Ö, Kayaçetin S.
europepmc   +1 more source