Results 21 to 30 of about 70,351 (245)
Nature Communications, 2021 Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap ...
Felipe A. Calil +6 more
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The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.
PLoS Genetics, 2015 During replication, mismatch repair proteins recognize and repair mispaired bases that escape the proofreading activity of DNA polymerase. In this work, we tested the model that the eukaryotic mismatch recognition complex tracks with the advancing ...
Joanna E Haye, Alison E Gammie
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Genes and Environment, 2018 Background A wide variety of DNA lesions interfere with replication and transcription, leading to mutations and cell death. DNA repair mechanisms act upon these DNA lesions present in the genomic DNA. To investigate a DNA repair mechanism elaborately, an
Mika Yukutake +3 more
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eLife, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Yi Yin +3 more
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MMR markers correlate with clinical outcome in patients with esophageal squamous cell carcinoma
The International Journal of Biological Markers, 2023 Background The DNA mismatch repair system is one of the defense mechanisms in the body, and the inactivation of mismatch repair plays a pivotal role in secondary carcinogenesis and progression.
Takuro Yamauchi +12 more
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Mutational spectrum of DNA damage and mismatch repair genes in prostate cancer
Frontiers in Genetics, 2023 Over the past few years, a number of studies have revealed that a significant number of men with prostate cancer had genetic defects in the DNA damage repair gene response and mismatch repair genes.
Fidelis Charles Bugoye +7 more
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DNA mismatch repair system [PDF]
The FEBS Journal, 2006 The molecular mechanisms of the DNA mismatch repair (MMR) system have been uncovered over the last decade, especially in prokaryotes. The results obtained for prokaryotic MMR proteins have provided a framework for the study of the MMR system in eukaryotic organisms, such as yeast, mouse and human, because the functions of MMR proteins have been ...
Jun, SH, Kim, TG, Ban, C
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Journal of Hematology & Oncology, 2019 Immunotherapies have led to substantial changes in cancer treatment and have been a persistently popular topic in cancer research because they tremendously improve the efficacy of treatment and survival of individuals with various cancer types.
Pengfei Zhao +3 more
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DNA methyltransferase Dnmt1 and mismatch repair [PDF]
Oncogene, 2004 We have examined the relationship between DNA mismatch repair and deficiency of DNA methylation in a mouse embryonic cell line, Dnmt1-/- ES, with homologous deletion of the gene coding for the maintenance DNA methyltransferase Dnmt1. With the use of a sensitive PCR for the assay of two mononucleotide- and three dinucleotide microsatellite markers that ...
Keh-Yang, Wang, C-K, James Shen
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Journal of Nucleic Acids, 2010 DNA is subjected to many endogenous and exogenous damages. All organisms have developed a complex network of DNA repair mechanisms. A variety of different DNA repair pathways have been reported: direct reversal, base excision repair, nucleotide excision ...
Rihito Morita +9 more
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