Results 31 to 40 of about 297,565 (330)

Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae

Nature Communications, 2021
Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap ...
Felipe A. Calil, Bin-Zhong Li, Kendall A. Torres, Katarina Nguyen, Nikki Bowen, Christopher D. Putnam, Richard D. Kolodner   +6 more
doaj   +1 more source

The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.

PLoS Genetics, 2015
During replication, mismatch repair proteins recognize and repair mispaired bases that escape the proofreading activity of DNA polymerase. In this work, we tested the model that the eukaryotic mismatch recognition complex tracks with the advancing ...
Joanna E Haye, Alison E Gammie
doaj   +1 more source

A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR [PDF]

, 2012
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Garelnabi, EAE, Hartley, JA, Karodia, N, Kiakos, K, Li, L, Phillips, Roger, Pletsas, D, Wheelhouse, RT   +7 more
core   +1 more source

Oligo swapping method for in vitro DNA repair substrate containing a single DNA lesion at a specific site

Genes and Environment, 2018
Background A wide variety of DNA lesions interfere with replication and transcription, leading to mutations and cell death. DNA repair mechanisms act upon these DNA lesions present in the genomic DNA. To investigate a DNA repair mechanism elaborately, an
Mika Yukutake, Mika Hayashida, Narumi Shioi Aoki, Isao Kuraoka   +3 more
doaj   +1 more source

Signalling cell cycle arrest and cell death through the MMR System [PDF]

, 2006
Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core   +1 more source

Mutational spectrum of DNA damage and mismatch repair genes in prostate cancer

Frontiers in Genetics, 2023
Over the past few years, a number of studies have revealed that a significant number of men with prostate cancer had genetic defects in the DNA damage repair gene response and mismatch repair genes.
Fidelis Charles Bugoye, Fidelis Charles Bugoye, Rispah Torrorey-Sawe, Richard Biegon, Nazima Dharsee, Fidelice M. S. Mafumiko, Kirtika Patel, Simeon K. Mining   +7 more
doaj   +1 more source

Differential DNA mismatch repair underlies mutation rate variation across the human genome

Nature, 2015
Cancer genome sequencing has revealed considerable variation in somatic mutation rates across the human genome, with mutation rates elevated in heterochromatic late replicating regions and reduced in early replicating euchromatin.
F. Supek, Ben Lehner
semanticscholar   +1 more source

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy

Journal of Hematology & Oncology, 2019
Immunotherapies have led to substantial changes in cancer treatment and have been a persistently popular topic in cancer research because they tremendously improve the efficacy of treatment and survival of individuals with various cancer types.
Pengfei Zhao, Li Li, Xiaoyue Jiang, Qin Li   +3 more
doaj   +1 more source

DNA mismatch repair preferentially protects genes from mutation

Genome Research, 2018
Mutation is the source of genetic variation and fuels biological evolution. Many mutations first arise as DNA replication errors. These errors subsequently evade correction by cellular DNA repair, for example, by the well-known DNA mismatch repair (MMR ...
E. Belfield, Z. Ding, Fiona J. C. Jamieson, A. Visscher, S. Zheng, Aziz Mithani, N. Harberd   +6 more
semanticscholar   +1 more source

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

eLife, 2018
Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors
Karl P Hodel, Richard de Borja, Erin E Henninger, Brittany B Campbell, Nathan Ungerleider, Nicholas Light, Tong Wu, Kimberly G LeCompte, A Yasemin Goksenin, Bruce A Bunnell, Uri Tabori, Adam Shlien, Zachary F Pursell   +12 more
doaj   +1 more source