Results 91 to 100 of about 188,397 (314)

Theoretical analysis of mutation hotspots and their DNA sequence context specificity [PDF]

Mutation Research/Reviews in Mutation Research, 2003
Mutation frequencies vary significantly along nucleotide sequences such that mutations often concentrate at certain positions called hotspots. Mutation hotspots in DNA reflect intrinsic properties of the mutation process, such as sequence specificity, that manifests itself at the level of interaction between mutagens, DNA, and the action of the repair ...
Rogozin, Igor B., Pavlov, Youri I.
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators

, 2009
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in ...
Gilbert, RJ, Saunders, Nigel, Saunders, NJ, Sainsbury, Sarah, Saunders, Nigel J., Owens, Raymond, Sainsbury, S, Owens, RJ, Ren, J, Lane, Laura A., Ren, Jingshan, Stuart, David I., Robinson, CV, Robinson, Carol V., Owens, Raymond J., Gilbert, Robert J., Lane, LA, Gilbert, Robert, Stuart, DI, Stuart, David   +19 more
core   +1 more source

deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution [PDF]

, 2016
BACKGROUND: Analysis of somatic mutations provides insight into the mutational processes that have shaped the cancer genome, but such analysis currently requires large cohorts.
Rosenthal, R, Swanton, C, McGranahan, N, Taylor, BS, Javier Herrero, Herrero, J, Charles Swanton, Barry S. Taylor, Nicholas McGranahan, Rachel Rosenthal   +9 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro [PDF]

, 2010
Initiation of mammalian DNA replication can be reconstituted from isolated G1-phase nuclei and cell extracts, supplemented with cyclin-dependent protein kinases (CDKs).
Sercombe, Heather E, Ainscough, Justin F X, Coverley, Dawn, Copeland, Nikki A   +3 more
core  

Analysis of mutations of NF1 gene in three patients with neurofibromatosis type I

Pifu-xingbing zhenliaoxue zazhi
[Objective] To detect the gene mutations in three children with neurofibromatosis type1 (NF1), and explore the new pathogenic mutations and phenotypes of NF1. [Methods] Exome sequencing and targeted gene panels were performed in the probands to determine
LIN Yanyan, DONG Shuyan, WANG Huaiyu, LIN Lihang, XIAO Xuemin   +4 more
doaj   +1 more source

Tandem repeat DNA: applications in mutation analysis

Environmental Mutagen Research, 2005
Non-coding tandem repeat DNA sequences have high rates of mutation that facilitate the measurement of induced mutation in small sample sizes. It has been suggested that these loci may be useful biomarkers for heritable genetic mutation induced by exposure to genotoxic agents.
Yauk, Carole, Polyzos, Aris
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Arrhythmogenic Right Ventricular Dysplasia: Clinical Characteristics and Identification of Novel Desmosome Gene Mutations

Journal of the Formosan Medical Association, 2008
Background/Purpose: Desmosome gene mutations have been reported in patients with arrhythmogenic right ventricular dysplasia (ARVD). However, there are hardly any genetic studies in Asians.
Chih-Chieh Yu, Cheng-Han Yu, Chia-Hsiang Hsueh, Chi-Tung Yang, Jyh-Ming Juang, Juey-Jen Hwang, Jiunn-Lee Lin, Ling-Ping Lai   +7 more
doaj   +1 more source