Results 71 to 80 of about 188,397 (314)

Electrochemical biosensors for analysis of DNA point mutations in cancer research

Analytical and Bioanalytical Chemistry, 2022
Cancer is a genetic disease induced by mutations in DNA, in particular point mutations in important driver genes that lead to protein malfunctioning and ultimately to tumorigenesis. Screening for the most common DNA point mutations, especially in such genes as TP53, BRCA1 and BRCA2, EGFR, KRAS, or BRAF, is crucial to determine predisposition risk for ...
Ondraskova, Katerina, Sebuyoya, Ravery, Moranova, Ludmila, Holcakova, Jitka, Vonka, Petr, Hrstka, Roman, Bartosik, Martin   +6 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The evolution of genome compression and genomic novelty in RNA viruses

, 2007
The genomes of RNA viruses are characterized by their extremely small size and extremely high mutation rates ( typically 10 kb and 10(-4)/ base/ replication cycle, respectively), traits that are thought to be causally linked.
Rambaut, Andrew, Pybus, Oliver G., Belshaw, Robert   +2 more
core   +1 more source

Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study [PDF]

, 2011
Background: Originally believed to be a rare phenomenon, heteroplasmy - the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual - is emerging as an important component of eukaryotic genetic diversity ...
James Taylor, Paul, IM, Taylor, J, Goto, H, Kateryna D Makova, Makova, KD, Anton Nekrutenko, Ian M Paul, Afgan, E, Enis Afgan, Hiroki Goto, Nekrutenko, A, Benjamin Dickins, Dickins, B   +13 more
core   +1 more source

A comparison between mutational profiles in tumour tissue DNA and circulating tumour DNA in head and neck squamous cell carcinoma---A systematic review

, 2023
Head and neck cancer is the seventh most common malignancy globally. Head and neck squamous cell carcinoma (HNSCC) originates from squamous cells and 90% of HNC are HNSCC. The gold standard for diagnosing HNSCC is tissue biopsy.
Kenny, Lizbeth, Punyadeera, Chamindie, Vasani, Sarju, Hartel, Gunter, Duijf, Pascal Hg, Jones, Lee, Huang, Xiaomin, Leo, Paul   +7 more
core   +1 more source

Comprehensive cross cancer analyses reveal mutational signature cancer specificity

Quantitative Biology
Mutational signatures refer to distinct patterns of DNA mutations that occur in a specific context or under certain conditions. It is a powerful tool to describe cancer etiology.
Rui Xin, Limin Jiang, Hui Yu, Fengyao Yan, Jijun Tang, Yan Guo   +5 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Mutational signatures reveal mutual exclusivity of homologous recombination and mismatch repair deficiencies in colorectal and stomach tumors

Scientific Data, 2023
Decomposing somatic mutation spectra into mutational signatures and their corresponding etiologies provides a powerful approach for investigating the mechanism of DNA damage and repair.
Amir Farmanbar, Robert Kneller, Sanaz Firouzi   +2 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source