Results 51 to 60 of about 188,397 (314)
The high cancer incidence in young people in Italy: do genetic signatures reveal their environmental causes? [PDF]
Journal of Health and Social Sciences, 2016 The increased incidence of cancer in children and adolescents registered in Italy in the last few decades is one of the highest amongst Western countries. The causes are difficult to identify, but recent daily news and some epidemiological surveys, such
Ruggero Ridolfi
doaj +1 more source
PCR in the Analysis of Mutations in Mitochondrial DNA
Annals of Medicine, 1992 (1992). PCR in the Analysis of Mutations in Mitochondrial DNA. Annals of Medicine: Vol. 24, No. 3, pp. 201-205.
openaire +2 more sources
Nucleic acid mutation analysis using catalytic DNA
Nucleic Acids Research, 2000 The sequence specificity of the '10-23' RNA-cleaving DNA enzyme (deoxyribozyme) was utilised to discriminate between subtle differences in nucleic acid sequence in a relatively conserved segment of the L1 gene from a number of different human papilloma virus (HPV) genotypes.
M J, Cairns, A, King, L Q, Sun
openaire +3 more sources
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase
, 2013 The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
Stier, Ildikó +5 more
core +1 more source
Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli [PDF]
, 2011 The fidelity role of DNA polymerase I in chromosomal DNA replication in E. coli was investigated using the rpoB forward target. These experiments indicated that in a strain carrying a proofreading-exonuclease-defective form of Pol I (polAexo mutant) the ...
Jonczyk, Piotr +7 more
core +1 more source
Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2016 Cancer therapy largely depends on chemotherapeutic agents that generate DNA lesions. However, our understanding of the nature of the resulting lesions as well as the mutational profiles of these chemotherapeutic agents is limited.
Annie S. Tam +2 more
doaj +1 more source
Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency
JCI Insight, 2023 Diabetes commonly affects patients with cancer. We investigated the influence of diabetes on breast cancer biology using a 3-pronged approach that included analysis of orthotopic human tumor xenografts, patient tumors, and breast cancer cells exposed to ...
Gatikrushna Panigrahi +18 more
doaj +1 more source
A Classic Case of Maple Syrup Urine Disease and a Novel Mutation in the BCKDHA Gene [PDF]
Iranian Journal of Neonatology, 2017 Background: Maple syrup urine disease (MSUD) is an inherited branched-chain amino acid metabolic disorder caused by the deficiency in the branched-chain alpha-keto acid dehydrogenase (BCKD) complex.
Alieh Mirzaee +7 more
doaj +1 more source