Results 21 to 30 of about 2,027,606 (189)

Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia

mBio, 2015
The aminoglycosides are highly effective broad-spectrum antimicrobial agents. However, their efficacy is diminished due to enzyme-mediated covalent modification, which reduces affinity of the drug for the target ribosome.
Georgina Cox, Peter J. Stogios, Alexei Savchenko, Gerard D. Wright   +3 more
doaj   +1 more source

NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold [PDF]

, 2012
Nuclear factors NF90 and NF45 form a complex involved in a variety of cellular processes and are thought to affect gene expression both at the transcriptional and translational level.
Adams, Atlanta G. Cook, Barber, Bricogne, Chen, Collaborative computing project, n, Corthesy, Cowtan, Deng, Diebold, Duchange, Emsley, Fukuda, Gomila, Guan, Holm, Hoque, Isken, Isken, Isken, Kabsch, Kao, Kraft, Kuwano, Kuwano, Liao, Lo Conte, Marcoulatos, McCoy, Neplioueva, Orford, Parker, Parrott, Reichman, Sakamoto, Scarlett, Shamanna, Sheldrick, Shi, Shi, Shim, Stagno, Urszula M. Wolkowicz, Worringer, Xu, Yue, Zeqiraj, Zhao   +47 more
core   +1 more source

Characterization of the Microbial Resistome in Conventional and “Raised Without Antibiotics” Beef and Dairy Production Systems

Frontiers in Microbiology, 2019
Metagenomic investigations have the potential to provide unprecedented insights into microbial ecologies, such as those relating to antimicrobial resistance (AMR).
Pablo Rovira, Tim McAllister, Steven M. Lakin, Shaun R. Cook, Enrique Doster, Noelle R. Noyes, Maggie D. Weinroth, Xiang Yang, Jennifer K. Parker, Christina Boucher, Calvin W. Booker, Dale R. Woerner, Keith E. Belk, Paul S. Morley   +13 more
doaj   +1 more source

MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data. [PDF]

, 2017
Transfer RNA fragments (tRFs) are an established class of constitutive regulatory molecules that arise from precursor and mature tRNAs. RNA deep sequencing (RNA-seq) has greatly facilitated the study of tRFs.
Loher, Phillipe, Rigoutsos, Isidore, Telonis, Aristeidis G.   +2 more
core   +2 more sources

In Silico Assigned Resistance Genes Confer Bifidobacterium with Partial Resistance to Aminoglycosides but Not to Β-Lactams [PDF]

, 2013
peer-reviewedBifidobacteria have received significant attention due to their contribution to human gut health and the use of specific strains as probiotics.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, O'Connell-Motherway, Mary, Ross, R Paul, STANTON, CATHERINE, van Sinderen, Douwe   +6 more
core   +7 more sources

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

Biology Direct, 2012
Background Proteinaceous toxins are observed across all levels of inter-organismal and intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin systems implicated in intra-specific conflicts.
Zhang Dapeng, de Souza Robson F, Anantharaman Vivek, Iyer Lakshminarayan M, Aravind L   +4 more
doaj   +1 more source

Evaluation of NAD(+)-dependent DNA ligase of mycobacteria as a potential target for antibiotics [PDF]

, 2007
Mycobacteria contain genes for several DNA ligases, including ligA, which encodes a NAD+-dependent enzyme that has been postulated to be a target for novel antibacterial compounds.
Bowater, Richard P., Brzostek, Anna, Dziadek, Jarosław, Korycka-Machala, Malgorzata, Rumijowska-Galewicz, Anna, Rychta, Ewelina, Sayer, Heather R.   +6 more
core   +2 more sources

Biophysical and enzymatic properties of aminoglycoside adenylyltransferase AadA6 from Pseudomonas aeruginosa [PDF]

, 2015
The gene coding for the aminoglycoside adenylyltransferase (aadA6) from a clinical isolate of Pseudomonas aeruginosa was cloned and expressed in Escherichia coli strain BL21(DE3)pLysS.
Akdemir, G., Allaart, C.F., Berg, R. van den, Bergstra, S.A., Han, K.H., Kerstens, P.J.S.M., Landewe, R.B.M., Lems, W.F., Markusse, I.M., Ronday, H.K.   +9 more
core   +2 more sources

Direct comparison of nick-joining activity of the nucleic acid ligases from bacteriophage T4 [PDF]

, 2006
The genome of bacteriophage T4 encodes three polynucleotide ligases, which seal the backbone of nucleic acids during infection of host bacteria. The T4Dnl (T4 DNA ligase) and two RNA ligases [T4Rnl1 (T4 RNA ligase 1) and T4Rnl2] join a diverse array of ...
Amitsur, Arabshahi, Bebenek, Begley, Bellacosa, Blondal, Blondal, Cherepanov, Cherepanov, Clepet, Della, Desmond R. Bullard, Doherty, Engler, Fareed, Higgins, Ho, Ho, Kaufmann, Keppetipola, Kornberg, Kuhn, Lavesa-Curto, Lehman, Markham, Martins, Martins, Miller, Moore, Nandakumar, Nandakumar, Nandakumar, Nick McElhinny, Omari, Pascal, Pitcher, Pitcher, Richard P. Bowater, Rossi, Ruiz, Runnels, Rydberg, Sambrook, Sekiguchi, Shuman, Shuman, Snopek, Sriskanda, Stuart, Timson, Tomkinson, Wang, Wang, Weiss, Wilkinson, Wilkinson, Wilkinson, Wood, Wood, Worthey, Yin, Yin   +61 more
core   +5 more sources

Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]

, 2013
.Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap, A L’Hernault, A Wilm, AE Simon, Andrew M. Lever, AR Gruber, BI Klasens, D Chen, D Chen, D Yue, D Yue, E Madore, E Matsuo, EC Hutchinson, Emily Manktelow, EV Puglisi, H Heus, HD Cho, J Jia, JC Kenyon, Jonathan Lever, JR Gog, JT Patton, Laura E. Easton, LE Easton, M Barro, M Estes, MA Tortorici, MW Friederich, N Figueroa, P Annamalai, Peter J. Lukavsky, PJ Lukavsky, R Giegé, R Giegé, RC Olsthoorn, S Nishimura, SC Chen, SH Bernhart, Subhajit Biswas, T Nagaike, TW Dreher, TW Dreher, TW Dreher, TW Dreher, Ulrich Desselberger, W Li, Wilson Li   +47 more
core   +1 more source