Results 61 to 70 of about 2,027,606 (189)

Genomic surveillance of Neisseria gonorrhoeae to investigate the distribution and evolution of antimicrobial-resistance determinants and lineages [PDF]

, 2018
The first extensively drug resistant (XDR) Neisseria gonorrhoeae strain with high resistance to the extended-spectrum cephalosporin ceftriaxone was identified in 2009 in Japan, but no other strain with this antimicrobial-resistance profile has been ...
Deguchi, Takashi, Didelot, Xavier, Kawahata, Takuya, Kuroki, Toshiro, Lee, Ken-ichi, Morita, Masatomo, Nakayama, Shu-ichi, Ohnishi, Makoto, Ohya, Hitomi, Shimuta, Ken, Watanabe, Yuko, Yahara, Koji, Yasuda, Mitsuru   +12 more
core   +1 more source

The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of Acinetobacter baumannii From the Indigenous Orang Asli Community in Peninsular Malaysia

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Analysis of Acinetobacter baumannii from healthy individuals in a rural Malaysian community revealed significant genetic diversity, including novel sequence types. These isolates carry resistance genes and resemble clinical strains, highlighting their potential to cause disease despite their commensal origin.
Soo‐Sum Lean, Denise E. Morris, Rebecca Anderson, Ahmed Ghazi Alattraqchi, David W. Cleary, Stuart C. Clarke, Chew Chieng Yeo   +6 more
wiley   +1 more source

TENT5C functions as a corepressor in the ligand‐bound glucocorticoid receptor and estrogen receptor α complexes

The FEBS Journal, Volume 292, Issue 19, Page 5168-5184, October 2025.
TENT5C is a suppressor of ERα and GR transcriptional activation. A specific LXXLL motif in TENT5C, absent in the other members of the TENT5 subfamily, mediates a stable interaction with the Ligand Binding Domain of ERα but not with that of GR.
Yin Li, Lalith Perera, Rebecca S. He, Marine Baptissart, Robert M. Petrovich, Marcos Morgan   +5 more
wiley   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, Volume 599, Issue 18, Page 2674-2684, September 2025.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Comparing environmental DNA metabarcoding and underwater visual census to monitor tropical reef fishes

Environmental DNA, 2020
Environmental DNA (eDNA) analysis is a revolutionary method to monitor marine biodiversity from animal DNA traces. Examining the capacity of eDNA to provide accurate biodiversity measures in species-rich ecosystems such as coral reefs is a prerequisite ...
Andrea Polanco Fernández, V. Marques, Fabian Fopp, J. Juhel, G. Borrero-Pérez, M. Cheutin, Tony Dejean, Juan David González Corredor, Andrés Acosta‐Chaparro, R. Hocdé, David Eme, E. Maire, Manuel Spescha, A. Valentini, S. Manel, D. Mouillot, C. Albouy, L. Pellissier   +17 more
semanticscholar   +1 more source

Comprehensive Pan‐Cancer Analysis of TRNT1 as a Potential Biomarker for Breast Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT TRNT1, an RNA nucleotide transferase, plays a critical role in cellular processes and may be involved in cancer. However, its role in cancer has not been fully explored. This study aims to explore the potential significance of TRNT1 in cancer, particularly in breast cancer (BC) progression and prognosis.
Xinwei Li, Yue Meng, Bing Gu
wiley   +1 more source

Stress alters hypothalamic gene expression in adolescent male Golden hamsters

Journal of Neuroendocrinology, Volume 37, Issue 9, September 2025.
Abstract In Golden hamsters (Mesocricetus auratus), a two‐week exposure to chronic social stress in adolescence causes acceleration of agonistic behavior, enhanced adult aggression, impaired waiting impulsivity, and higher food intake, body fat, and long‐term increased body weight.
Kevin M. Moran, Tyler M. Milewski, James P. Curley, Yvon Delville   +3 more
wiley   +1 more source

Unusual evolution of a catalytic core element in CCA-adding enzymes [PDF]

, 2010
CCA-adding enzymes are polymerases existing in two distinct enzyme classes that both synthesize the C-C-A triplet at tRNA 3′-ends. Class II enzymes (found in bacteria and eukaryotes) carry a flexible loop in their catalytic core required for switching ...
Betat, Heike, Bluschke, Alexander, Günther, Robert, Hoffmeier, Andrea, Hofmann, Hans-Jörg, Junghanns, Sandy, Mörl, Mario   +6 more
core   +2 more sources

Enriched Shotgun Sequencing to Assess the Effects of Interventions to Reduce Antimicrobial Use in Neonatal Dairy Calves

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT Background Neonatal diarrhea accounts for 20%–25% of morbidity among calves, and antimicrobial drugs (AMDs) are often administered for treatment. Systematic approaches that mitigate antimicrobial use (AMU) can be effective in decreasing antimicrobial resistance (AMR).
Rebecca Flancman, Enrique Doster, Diego E. Gomez, Nicole Ricker, Paul S. Morley, J. Scott Weese   +5 more
wiley   +1 more source

Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer‐related gene in pancreatic cancer

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
HBV DNA integrates in multiple genes including KMT2B in pancreatic cancer. KMT2B upregulation caused by HBV integration or other mechanisms promotes FYN expression via histone H3K4 trimethylation at its promoter region. Increased FYN expression activates the PI3K/Akt signalling pathway, thus driving PDAC cell proliferation, migration and invasion ...
Mengge Li, Huimin Li, Dejun Liu, Shunan Liu, Hui Yuan, Yan Wu, Min Du, Yuan Fang, Jin Li, Hui Cong, Dan Zhao, Chunsun Fan, Qing Wang, Cenkai Shen, Yu Gan, Yongwei Sun, Hong Tu   +16 more
wiley   +1 more source