Results 61 to 70 of about 6,763 (148)

Unusual evolution of a catalytic core element in CCA-adding enzymes [PDF]

, 2010
CCA-adding enzymes are polymerases existing in two distinct enzyme classes that both synthesize the C-C-A triplet at tRNA 3′-ends. Class II enzymes (found in bacteria and eukaryotes) carry a flexible loop in their catalytic core required for switching ...
Betat, Heike, Bluschke, Alexander, Günther, Robert, Hoffmeier, Andrea, Hofmann, Hans-Jörg, Junghanns, Sandy, Mörl, Mario   +6 more
core   +2 more sources

Enriched Shotgun Sequencing to Assess the Effects of Interventions to Reduce Antimicrobial Use in Neonatal Dairy Calves

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT Background Neonatal diarrhea accounts for 20%–25% of morbidity among calves, and antimicrobial drugs (AMDs) are often administered for treatment. Systematic approaches that mitigate antimicrobial use (AMU) can be effective in decreasing antimicrobial resistance (AMR).
Rebecca Flancman, Enrique Doster, Diego E. Gomez, Nicole Ricker, Paul S. Morley, J. Scott Weese   +5 more
wiley   +1 more source

Synthesis and repair of 3'-end of tRNA molecule by tRNA nucleotidyltransferase [PDF]

, 2010
Enzim ATP(CTP):tRNA-nukleotidil-transferaza (CCA enzim) katalizira posttranskripcijsku sintezu i popravak slijeda CCA na 3'-kraju molekule tRNA, neophodnog u reakcijama translacije i stoga od životne važnosti za stanicu.
Hajdinjak, Mateja
core   +2 more sources

Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer‐related gene in pancreatic cancer

Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.
HBV DNA integrates in multiple genes including KMT2B in pancreatic cancer. KMT2B upregulation caused by HBV integration or other mechanisms promotes FYN expression via histone H3K4 trimethylation at its promoter region. Increased FYN expression activates the PI3K/Akt signalling pathway, thus driving PDAC cell proliferation, migration and invasion ...
Mengge Li, Huimin Li, Dejun Liu, Shunan Liu, Hui Yuan, Yan Wu, Min Du, Yuan Fang, Jin Li, Hui Cong, Dan Zhao, Chunsun Fan, Qing Wang, Cenkai Shen, Yu Gan, Yongwei Sun, Hong Tu   +16 more
wiley   +1 more source

Solution, solid-phase, and fluorous-phase synthesis of carbohydrates and production of carbohydrate microarrays [PDF]

, 2006
This dissertation focuses on two specific aspects of the chemistry of carbohydrates. The first is the solid- and fluorous-phase synthesis of oligosaccharides and their use in forming microarrays.
Ko, Kwang-Seuk
core   +2 more sources

3D Tumor microenvironment interaction reveals AP‐1 complex regulation and contact‐mediated reprogramming of bone marrow stromal cells in chronic lymphocytic leukemia

HemaSphere, Volume 9, Issue 8, August 2025.
Abstract Chronic lymphocytic leukemia (CLL) cells actively reprogram their tumor microenvironment (TME) to promote drug resistance and tumor progression. Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironment, particularly bone marrow‐derived stromal cells (BMSCs).
Jana Lindacher, Anne Hartebrodt, Janin Dingfelder, Pascal Lukas, Laeschkir Würthner, Simon Völkl, David B. Blumenthal, Frederik Graw, Kerstin Amann, Manuela Krumbholz, Martina Haibach, Jochen Wilke, Andreas Mackensen, Gloria Lutzny‐Geier   +13 more
wiley   +1 more source

Expanding the diversity of mycobacteriophages: Insights into genome architecture and evolution [PDF]

, 2011
Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes ...
Agustin, B, Al-Atrache, Z, Alcoser, TA, Alexander, LM, Alfano, MB, Alford, ST, Amy, NE, Anderson, AG, Anderson, MD, Ang, AAS, Barber, AJ, Barker, LP, Barrett, JM, Barshop, WD, Bauerle, CM, Bayles, IM, Belfield, KL, Best, AA, Bowman, CA, Boyer, CA, Bradley, KW, Bradley, VA, Broadway, LN, Budwal, K, Busby, KN, Campbell, AM, Campbell, IW, Carey, A, Caruso, SM, Chew, RD, Cockburn, CL, Cohen, LB, Corajod, JM, Cresawn, SG, Davis, KR, Deng, L, Denver, DR, Dixon, BR, Ekram, S, Elgin, SCR, Engelsen, AE, English, BEV, Erb, ML, Estrada, C, Filliger, LZ, Findley, AM, Forbes, L, Forsyth, MH, Fox, TM, Fritz, MJ, Garcia, R, George, ZD, Georges, AE, Gissendanner, CR, Goff, S, Goldstein, R, Gordon, KC, Green, RD, Guerra, SL, Guiney-Olsen, KR, Guiza, BG, Haghighat, L, Hagopian, GV, Harmon, CJ, Harmson, JS, Hartzog, GA, Harvey, SE, He, KJ, He, S, Healy, KE, Higinbotham, ER, Hildebrandt, EN, Ho, JH, Hogan, GM, Hohenstein, VG, Holz, NA, Huang, VJ, Hufford, EL, Hynes, PM, Jackson, AS, Jacobs-Sera, D, Jansen, EC, Jarvik, J, Jasinto, PG, Jordan, TC, Kasza, T, Katelyn, MA, Kelsey, JS, Kerrigan, LA, Khaw, D, Kim, J, Knutter, JZ, Ko, CC, Larkin, GV, Laroche, JR, Latif, A, Manuel, A, Peebles, CL, Pope, WH, Russel, DA   +99 more
core   +1 more source

ant(6)-I Genes encoding aminoglycoside O-nucleotidyltransferases are widely spread among Streptomycin resistant strains of Campylobacter jejuni and Campylobacter coli [PDF]

, 2018
info:eu-repo/semantics ...
Borge, Carmen, Campos, Maria, Domínguez, Lucas, Florez-Cuadrado, Diego, Hormeño, Lorena, Palomo, Gonzalo, Píriz, Segundo, Quesada, Alberto, Ugarte-Ruiz, María, Vadillo, Santiago   +9 more
core   +3 more sources

Deinococcus radiodurans RNA ligase exemplifies a novel ligase clade with a distinctive N-terminal module that is important for 5′-PO(4) nick sealing and ligase adenylylation but dispensable for phosphodiester formation at an adenylylated nick [PDF]

, 2007
Deinococcus radiodurans RNA ligase (DraRnl) is a template-directed ligase that seals nicked duplexes in which the 3′-OH strand is RNA. DraRnl is a 342 amino acid polypeptide composed of a C-terminal adenylyltransferase domain fused to a distinctive 126 ...
Raymond, Amy, Shuman, Stewart
core   +2 more sources

Probing carbohydrate biocatalysis through the use of electrospray ionization mass spectrometry and isothermal titration calorimetry [PDF]

, 2005
Electrospray ionization mass spectrometry,(ESI-MS)-based assays have been newly developed to study three classes of enzymes (sugar nucleotidyltransferases, glycosyltransferases, and phosphorylases) from the three distinct families of life: archaea ...
Zea, Corbin James
core   +3 more sources