Results 201 to 210 of about 3,282,036 (289)

Fabrication of Multimodal Anion Exchange Membrane for Chromatographic Purification of Full Adeno‐Associated Viral Capsids

Advanced Materials Interfaces, EarlyView.
A novel multi‐modal anion exchange membrane (MMAEX) is successfully fabricated for separating empty and full AAV2 capsids. The functionalized membrane has an average pore size of 0.5 µm and exhibits both charge and hydrophobic functionality. A full capsid recovery of 72.9% at 85.3% purity with gradient elution, or 70.3% recovery at 92.2% purity with ...
Xiaolei Hao, Sumith Ranil Wickramasinghe, Xianghong Qian   +2 more
wiley   +1 more source

Structural basis of error-prone DNA synthesis by DNA polymerase θ. [PDF]

Nat Commun
Li C, Maksoud LM, Gao Y.
europepmc   +1 more source

Antimicrobial Multi‐Assay Evaluation of (Al‐Doped ZnO)‐Ag and TiO2‐Ag Nanocoatings: Impact of Direct and Indirect Mechanisms

Advanced Materials Interfaces, EarlyView.
This work explores the antimicrobial action of AZO‐Ag and TiO2‐Ag nanocoatings on plastic, demonstrating good efficacy against highly‐critical antibiotic‐resistant bacteria, yeast, and virus. A multi‐assay approach is here exploited to inspect the contribution of direct and indirect antimicrobial mechanisms, and potential human toxicity is also ...
Damiano Squitieri, Roberta Vitali, Cecilia Bartoleschi, Giulia Lombardini, Margherita Cacaci, Lorenzo Degli Esposti, Camilla Fusacchia, Skerxho Osmani, Luca Gavioli, Francesca Bugli, Daniele Valerini   +10 more
wiley   +1 more source

Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β. [PDF]

Nat Commun
Weaver TM, Ryan BJ, Thompson SH, Hussen AS, Spencer JJ, Xu Z, Schnicker NJ, Freudenthal BD.   +7 more
europepmc   +1 more source

Smart Sampling Capsule for Capture and Detection of Enteric Pathogens in the Small Intestine

Advanced Materials Technologies, EarlyView.
An ingestible smart sampling capsule for capturing asymptomatic enteric pathogens at their primary sites of interaction within the small intestine. This capability enables non‐invasive detection of early pathogen colonization within the gut environment prior to fecal shedding, providing a robust approach for pathogen surveillance and microbiome studies.
Akshay Krishnakumar, Devendra Sarnaik, Nicholas L. F. Gallina, Robyn R. McCain, Christa Crain, Arun K. Bhunia, Rahim Rahimi   +6 more
wiley   +1 more source

3D‐Printed Unibody Microfluidic Devices for Organ‐on‐Chip Applications

Advanced Materials Technologies, EarlyView.
A practical approach is demonstrated to 3D printing unibody microfluidic Organ‐on‐Chip (OoC) devices using commercial resins and desktop DLP printers. The demonstrated functional devices support 2D monolayers, 3D spheroids, and barrier tissues. With optimised design and post‐processing techniques, leak‐free, biocompatible microchannels and membranes ...
Louis Jun Ye Ong, Surasak Kasetsirikul, Laura A. Milton, Xiaolei Nie, Andrea W. Eiken, James Chirnside, Lucy‐May Gillian Young, Gregory P. Nordin, Yi‐Chin Toh   +8 more
wiley   +1 more source

The CIC::DUX4 oncoprotein maintains DNA integrity through direct regulation of the catalytic subunit of DNA polymerase epsilon (POLE). [PDF]

Oncogene
Kosibaty Z, Luck C, Okimoto RA.
europepmc   +1 more source

Implementation of FTA Elute Card for Viral RNA Storage and Cost‐Effective Wastewater Surveillance

Advanced Sensor Research, EarlyView.
A strategy is developed for room‐temperature storage of RNA from wastewater using FTA Elute cards, which allow for easy and portable transportation. FTA Elude cards provided a 15.4% recovery of the original RNA with cards, compared to only 0.5% recovery without cards.
Qingxin Hui, Yuwei Pan, David Cullen, Zhugen Yang   +3 more
wiley   +1 more source

DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint. [PDF]

DNA Repair (Amst)
Khan MM, Roos WP, Pearson CR, Leonard SM, Angajala A, Gibbs DY, Liu JC, Ragin C, Sobol RW.   +8 more
europepmc   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source