Results 251 to 260 of about 875,099 (273)
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Annual Review of Biochemistry, 2002
▪ Abstract Any living cell is faced with the fundamental task of keeping the genome intact in order to develop in an organized manner, to function in a complex environment, to divide at the right time, and to die when it is appropriate. To achieve this goal, an efficient machinery is required to maintain the genetic information encoded in DNA during ...
Hubscher U, Maga G, Spadari S
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▪ Abstract Any living cell is faced with the fundamental task of keeping the genome intact in order to develop in an organized manner, to function in a complex environment, to divide at the right time, and to die when it is appropriate. To achieve this goal, an efficient machinery is required to maintain the genetic information encoded in DNA during ...
Hubscher U, Maga G, Spadari S
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Current Protocols in Molecular Biology, 2008
AbstractThis unit presents characteristics and reaction conditions of the DNA‐dependent DNA polymerases, including E. coli DNA polymerase I and its Klenow fragment, T4 DNA polymerase, native and modified T7 DNA polymerase, phi29 DNA polymerase, Bst DNA polymerase, and Taq DNA polymerase. The unit also provides overviews of other classes of thermophilic
Rebecca Kucera, Nicole M. Nichols
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AbstractThis unit presents characteristics and reaction conditions of the DNA‐dependent DNA polymerases, including E. coli DNA polymerase I and its Klenow fragment, T4 DNA polymerase, native and modified T7 DNA polymerase, phi29 DNA polymerase, Bst DNA polymerase, and Taq DNA polymerase. The unit also provides overviews of other classes of thermophilic
Rebecca Kucera, Nicole M. Nichols
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Biochemical and Biophysical Research Communications, 1971
Summary Homogeneous DNA polymerases from E. coli and sea urchins contain zinc in a proportion of approximately 2 and 4 gm atoms Zn/mole enzyme respectively. Specific inhibition of the enzyme by ortho -phenanthroline and lack of inhibition by meta -phenanthroline suggest that the bound zinc plays a functional role in the interaction of DNA with ...
Albert S. Mildvan +2 more
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Summary Homogeneous DNA polymerases from E. coli and sea urchins contain zinc in a proportion of approximately 2 and 4 gm atoms Zn/mole enzyme respectively. Specific inhibition of the enzyme by ortho -phenanthroline and lack of inhibition by meta -phenanthroline suggest that the bound zinc plays a functional role in the interaction of DNA with ...
Albert S. Mildvan +2 more
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Nature, 1974
DNA polymerase has been isolated from the cytoplasm of several mammalian tissues as well as several cell lines in culture1–8. This has been puzzling because DNA replication and repair are processes generally believed to be restricted to the nucleus, where chromatin is located.
Kathleen M. Downey +3 more
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DNA polymerase has been isolated from the cytoplasm of several mammalian tissues as well as several cell lines in culture1–8. This has been puzzling because DNA replication and repair are processes generally believed to be restricted to the nucleus, where chromatin is located.
Kathleen M. Downey +3 more
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Current Opinion in Structural Biology, 2018
The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS).
Aneel K. Aggarwal +2 more
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The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS).
Aneel K. Aggarwal +2 more
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Annual Review of Biochemistry, 1977
PERSPECTIVES A ND SU MMARY ......... 25 IN TR ODUCTION ........ ... 27 CE LLU LAR DNA POL YMERASES ....... . 28 DNA Polymerase a ......... 28 DNA Polymerase /3 31 DNA Polymerase 'Y •.....• • 33 Mitochondrial DNA Polymerase .... ......... 34 VIR US-INDUCED DNA POL YMERASES ......... ....
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PERSPECTIVES A ND SU MMARY ......... 25 IN TR ODUCTION ........ ... 27 CE LLU LAR DNA POL YMERASES ....... . 28 DNA Polymerase a ......... 28 DNA Polymerase /3 31 DNA Polymerase 'Y •.....• • 33 Mitochondrial DNA Polymerase .... ......... 34 VIR US-INDUCED DNA POL YMERASES ......... ....
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DNA polymerases and carcinogenesis
Biochemistry (Moscow), 2010There are many various chromosomal and gene mutations in human cancer cells. The total mutation rate in normal human cells is 2·10(-7) mutations/gene/division. From 6 to 12 carcinogenic mutations can arise by the end of the life, and these can affect the structure of ~150 protooncogenes and genes encoding suppressors of tumor growth. However, this does
T. P. Kravetskaya, V. M. Krutyakov
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Nature, 1970
A membrane associated DNA polymerizing enzyme has been solubilized, partially isolated and characterized.
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A membrane associated DNA polymerizing enzyme has been solubilized, partially isolated and characterized.
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