Results 81 to 90 of about 727,025 (334)

DNA-Mediated Electrochemistry [PDF]

, 2008
The base pair stack of DNA has been demonstrated as a medium for long-range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with
Barton, Jacqueline K., Buzzeo, Marisa C., Gorodetsky, Alon A.   +2 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

TopBP1 utilises a bipartite GINS binding mode to support genome replication

Nature Communications
Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance.
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos   +13 more
doaj   +1 more source

A Nick-sensing DNA 3′-Repair Enzyme fromArabidopsis [PDF]

Journal of Biological Chemistry, 2002
DNA single-strand breaks, a major cause of genome instability, often produce unconventional end groups that must be processed to restore terminal moieties suitable for reparative DNA gap filling or ligation. Here, we describe a bifunctional repair enzyme from Arabidopsis (named AtZDP) that recognizes DNA strand breaks and catalyzes the removal of 3 ...
PETRUCCO, Stefania, BOLCHI, Angelo, RIVETTI, Claudio, OTTONELLO, Simone, VOLPI G.   +4 more
openaire   +3 more sources

Fertilization capacity with rainbow trout DNA-damaged sperm and embryo developmental success [PDF]

, 2010
Mammalian spermatozoa undergo a strong selection process along the female tract to guarantee fertilization by good quality cells, but risks of fertilization with DNA-damaged spermatozoa have been reported.
Ahmadi, Andrabi, Barroso, Baumber, Beirao, Cabrita, Evenson, Flajshans, Fortier, Hakem, Hales, Holt, Hu, Irvine, J Beirão, Jalabert, Jaroudi, Lee, Li, Liao, M P Herráez, Maluszynska, Matsuda, S Martínez-Páramo, S Pérez-Cerezales, Satake, Schulte, Singh, Sun, Tam, Tarin, Yeates   +31 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA Repair

Stem Cell Reports, 2017
Summary: Human embryonic stem cells (hESCs) hold great promise for the treatment of many incurable diseases. Sirtuin1 (SIRT1), a class III histone deacetylase, is abundantly expressed in hESCs and is known to regulate early differentiation and telomere ...
Jiho Jang, Yong Jun Huh, Hyun-Ju Cho, Boram Lee, Jaepil Park, Dong-Youn Hwang, Dong-Wook Kim   +6 more
doaj   +1 more source

Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases [PDF]

, 2007
Background Major genomic surveillance mechanisms regulated in response to DNA damage exist at the G1/S and G2/M checkpoints. It is presumed that these delays provide time for the repair of damaged DNA. Cells have developed multiple DNA repair pathways to
Chaudhry M Ahmad
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mechanism for CCC DNA synthesis in hepadnaviruses. [PDF]

PLoS ONE, 2009
Hepadnavirus replication requires the synthesis of a covalently closed circular (CCC) DNA from the relaxed circular (RC) viral genome by an unknown mechanism.
Ji A Sohn, Samuel Litwin, Christoph Seeger   +2 more
doaj   +1 more source