Results 1 to 10 of about 149 (149)

Adenovirus DNA Replication [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2013
Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents.
Hoeben, R.C., Uil, T.G.
openaire   +3 more sources

Chromatin and DNA Replication [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2013
The size of a eukaryotic genome presents a unique challenge to the cell: package and organize the DNA to fit within the confines of the nucleus while at the same time ensuring sufficient dynamics to allow access to specific sequences and features such as genes and regulatory elements.
D. M. MacAlpine, G. Almouzni
openaire   +3 more sources

Origins of DNA replication

open access: yesPLOS Genetics, 2019
In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes.
Babatunde Ekundayo, Franziska Bleichert
openaire   +5 more sources

Replicative DNA Polymerases [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2013
In 1959, Arthur Kornberg was awarded the Nobel Prize for his work on the principles by which DNA is duplicated by DNA polymerases. Since then, it has been confirmed in all branches of life that replicative DNA polymerases require a single-stranded template to build a complementary strand, but they cannot start a new DNA strand de novo.
Johansson, Erik, Dixon, Nicholas
openaire   +4 more sources

DNA Replication Fidelity [PDF]

open access: yesJournal of Biological Chemistry, 1992
▪ Abstract DNA replication fidelity is a key determinant of genome stability and is central to the evolution of species and to the origins of human diseases. Here we review our current understanding of replication fidelity, with emphasis on structural and biochemical studies of DNA polymerases that provide new insights into the importance of hydrogen ...
openaire   +3 more sources

DNA Replication Origins [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2013
The onset of genomic DNA synthesis requires precise interactions of specialized initiator proteins with DNA at sites where the replication machinery can be loaded. These sites, defined as replication origins, are found at a few unique locations in all of the prokaryotic chromosomes examined so far.
A. C. Leonard, M. Mechali
openaire   +3 more sources

Conservative DNA Replication [PDF]

open access: yesNature Reviews Molecular Cell Biology, 2014
Thanos D. Halazonetis describes the discovery that break-induced replication is conservative in budding yeast.
openaire   +3 more sources

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Replicating repetitive DNA

open access: yesNature Cell Biology, 2016
The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.
Christian Speck   +2 more
openaire   +5 more sources

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

open access: yesFEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring   +6 more
wiley   +1 more source

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