Results 1 to 10 of about 3,840,898 (210)
Control of DNA replication timing in the 3D genome
Nature Reviews Molecular Cell Biology, 2019 The 3D organization of mammalian chromatin was described more than 30 years ago by visualizing sites of DNA synthesis at different times during the S phase of the cell cycle. These early cytogenetic studies revealed structurally stable chromosome domains
Claire Marchal +2 more
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DNA replication and beyond [PDF]
Nature Reviews Molecular Cell Biology, 2016 It turns out that Meselson and Stahl were not the first to show that DNA replicates semi-conservatively. The preceding experiment was almost forgotten, partly because it showed something incredible.
Joseph G Gall, Gall Joseph G
exaly +3 more sources
Mechanisms of DNA replication termination
Nature Reviews Molecular Cell Biology, 2017 Genome duplication is carried out by pairs of replication forks that assemble at origins of replication and then move in opposite directions. DNA replication ends when converging replication forks meet.
James M Dewar +2 more
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Cell, 2017 Summary Conflicts between transcription and replication are a potent source of DNA damage. Co-transcriptional R-loops could aggravate such conflicts by creating an additional barrier to replication fork progression. Here, we use a defined episomal system
Stephan Hamperl +2 more
exaly +2 more sources
Processing ribonucleotides incorporated during eukaryotic DNA replication
Nature Reviews Molecular Cell Biology, 2016 The information encoded in DNA is influenced by the presence of non-canonical nucleotides, the most frequent of which are ribonucleotides. In this Review, we discuss recent discoveries about ribonucleotide incorporation into DNA during replication by the
R Scott Williams +2 more
exaly +2 more sources
Hallmarks of DNA Replication Stress
Molecules and Cells, 2022 SUMMARY Faithful DNA replication is critical for the maintenance of genomic integrity. While the DNA replication machinery is highly accurate, the process of DNA replication is constantly challenged by DNA damage and other intrinsic and extrinsic ...
Sneha Saxena, L. Zou
semanticscholar +1 more source
Origins of DNA Replication in Eukaryotes
Molecules and Cells, 2023 Errors occurring during DNA replication can result in inaccurate, incomplete or re-replication, resulting in genome instability that can lead to diseases such as cancer or disorders such as autism.
Yixin Hu, B. Stillman
semanticscholar +1 more source
The Initiation of Eukaryotic DNA Replication.
Annual Review of Biochemistry, 2022 DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell cycle.
Alessandro Costa, J. Diffley
semanticscholar +1 more source
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
Frontiers in Cell and Developmental Biology, 2021 DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell
Rafaela Fagundes, Leonardo K Teixeira
semanticscholar +1 more source
Advances in Experimental Medicine and Biology, 2019 Deoxyribonucleic acid replication is the process leading to the duplication of genetic material in an organism.
J. Seto
semanticscholar +3 more sources