Results 1 to 10 of about 3,806,270 (196)
Hallmarks of DNA replication stress.
Molecules and Cells, 2022 Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA replication machinery is highly accurate, the process of DNA replication is constantly challenged by DNA damage and other intrinsic and extrinsic stresses ...
Sneha Saxena, L. Zou
semanticscholar +1 more source
Origins of DNA replication in eukaryotes.
Molecules and Cells, 2023 Errors occurring during DNA replication can result in inaccurate replication, incomplete replication, or re-replication, resulting in genome instability that can lead to diseases such as cancer or disorders such as autism.
Yixin Hu, B. Stillman
semanticscholar +1 more source
The Initiation of Eukaryotic DNA Replication.
Annual Review of Biochemistry, 2022 DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell cycle.
Alessandro Costa, J. Diffley
semanticscholar +1 more source
Cyclin E/CDK2: DNA Replication, Replication Stress and Genomic Instability
Frontiers in Cell and Developmental Biology, 2021 DNA replication must be precisely controlled in order to maintain genome stability. Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases (CDKs) in association with respective cyclin regulatory subunits. In normal cell
Rafaela Fagundes, Leonardo K Teixeira
semanticscholar +1 more source
Advances in Experimental Medicine and Biology, 2019 Deoxyribonucleic acid replication is the process leading to the duplication of genetic material in an organism.
J. Seto
semanticscholar +3 more sources
MTBP phosphorylation controls DNA replication origin firing
Scientific Reports, 2021 Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR and Sld2 ...
Pedro Ferreira +12 more
doaj +1 more source
Nature Communications, 2022 Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how
Almutasem Saleh +9 more
doaj +1 more source
The Contribution of Lysosomes to DNA Replication
Cells, 2021 Lysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for
Joanna Maria Merchut-Maya +1 more
doaj +1 more source
Adenovirus DNA Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents.
Hoeben, R.C., Uil, T.G.
openaire +3 more sources
DNA Replication Fidelity [PDF]
Annual Review of Biochemistry, 2000 ▪ Abstract DNA replication fidelity is a key determinant of genome stability and is central to the evolution of species and to the origins of human diseases. Here we review our current understanding of replication fidelity, with emphasis on structural and biochemical studies of DNA polymerases that provide new insights into the importance of hydrogen
T A, Kunkel, K, Bebenek
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