Results 1 to 10 of about 917,051 (359)
Proteomic data on the nuclear interactome of human MCM9
Data in Brief, 2016 We present data relating to the interactome of MCM9 from the nuclei of human cells. MCM9 belongs to the AAA+ superfamily, and contains an MCM domain and motifs that may confer DNA helicase activity.
James R.A. Hutchins +6 more
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Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]
, 2010 In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Alexander M. Thomson +64 more
core +4 more sources
A CDK-regulated chromatin segregase promoting chromosome replication
Nature Communications, 2021 How cells coordinate chromatin dynamics with the cell cycle machinery to promote genome duplication during S phase is still a matter of study. Here the authors reveal by in vitro reconstitution assays that the AAA + -ATPase containing Yta7 protein in S ...
Erika Chacin +11 more
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Purification and characterization of a novel archaeo-eukaryotic primase from Mimivirus [PDF]
arXiv, 2016 DNA replication is a process which is common to all domains of life yet different replication mechanisms are seen among different organisms. The mechanism of replication on such a structure is not yet understood. With this bigger picture in mind, we have initiated the characterization involved in DNA replication.
arxiv
Journal of Biological Chemistry, 1983 In this review, we will summarize new approaches to the study of DNA replication in yeast made possible by recombinant DNA technology, and in particular, survey results obtained with in vitro replication systems. Other recent reviews that summarize previous yeast replication studies are those of Fangman and Zakian and Petes.
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DNA replication and beyond [PDF]
Nature Reviews Molecular Cell Biology, 2016 It turns out that Meselson and Stahl were not the first to show that DNA replicates semi-conservatively. The preceding experiment was almost forgotten, partly because it showed something incredible.
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Cold Spring Harbor Perspectives in Biology, 2013 Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin structure, and genome evolution. Recent advances in genome-scale mapping of replication kinetics have allowed these correlations to be explored in many species, cell types, and growth conditions, and these large data sets have allowed quantitative and ...
Rhind, Nicholas R., Gilbert, David M.
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MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing
Nature CommunicationsOrigin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7 onto replication origins in G1-phase forms the basis of replication fork establishment in S-phase.
L. Maximilian Reuter +6 more
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The Replication of Polyoma DNA
Journal of General Virology, 1973 Summary Measurement of replicating molecules of polyoma virus DNA after digestion with endonuclease R1 shows that DNA replication is bidirectional, starting predominantly at a specific site. In both large plaque and small plaque polyoma virus DNA this site is 29 ± 2% of the total length of the DNA from the cleavage site of the endonuclease R1.
Annelie Wilde +2 more
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The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA. [PDF]
, 2011 In the early 'RNA world' stage of life, RNA stored genetic information and catalyzed chemical reactions. However, the RNA world eventually gave rise to the DNA-RNA-protein world, and this transition included the 'genetic takeover' of information storage ...
Chen, Irene A +4 more
core +4 more sources