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THE REPLICATION OF THE DNA MOLECULE [PDF]
Proceedings of the National Academy of Sciences, 1964 Patrick S.W. Fong
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Acceleration of DNA Replication of Klenow Fragment by Small Resisting Force [PDF]
Chin. Phys. Lett. 2021, 38 (11): 118701, 2021 DNA polymerases are an essential class of enzymes or molecular motors that catalyze processive DNA syntheses during DNA replications. A critical issue for DNA polymerases is their molecular mechanism of processive DNA replication. We have previously proposed a model for chemomechanical coupling of DNA polymerases, based on which the predicted results ...
arxiv +1 more source
MTBP phosphorylation controls DNA replication origin firing
Scientific Reports, 2021 Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR and Sld2 ...
Pedro Ferreira +12 more
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Nature Communications, 2022 Here the authors describe multiple structures of the replicative helicase MCM2-7 in complex with Dbf4-dependent kinase (DDK). These structures reveal why the kinase specifically recognizes the MCM2-7 double-hexamer over the single-hexamer and explain how
Almutasem Saleh +9 more
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The Contribution of Lysosomes to DNA Replication
Cells, 2021 Lysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for
Joanna Maria Merchut-Maya +1 more
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eLife, 2022 RFC uses ATP to assemble PCNA onto primed sites for replicative DNA polymerases δ and ε. The RFC pentamer forms a central chamber that binds 3′ ss/ds DNA junctions to load PCNA onto DNA during replication.
Fengwei Zheng +4 more
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Adenovirus DNA Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Adenoviruses have attracted much attention as probes to study biological processes such as DNA replication, transcription, splicing, and cellular transformation. More recently these viruses have been used as gene-transfer vectors and oncolytic agents.
Hoeben, R.C., Uil, T.G.
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Nature Communications, 2021 Eukaryotic DNA replication is mediated by many proteins which are tightly regulated for an efficient firing of replication at each cell cycle. Here the authors report a cryo-EM structure of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA revealing ...
Xiang Feng +5 more
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Genome replication in asynchronously growing microbial populations [PDF]
, 2023 Biological cells replicate their genomes in a well-planned manner. The DNA replication program of an organism determines the timing at which different genomic regions are replicated, with fundamental consequences for cell homeostasis and genome stability.
arxiv +1 more source
eLife, 2020 Cell cycle tags allow to restrict target protein expression to specific cell cycle phases. Here, we present an advanced toolbox of cell cycle tag constructs in budding yeast with defined and compatible peak expression that allow comparison of protein ...
Julia Bittmann +6 more
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