Results 201 to 210 of about 178,865 (248)

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

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The Initiation of Eukaryotic DNA Replication

Annual Review of Biochemistry, 2022
DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell cycle. This is accomplished through the regulation of the first two steps in replication: loading and activation ...
Alessandro, Costa, John F X, Diffley
openaire   +4 more sources

Initiation of DNA replication in multicellular eukaryotes

Journal of Structural Biology, 2002
Three questions central to understanding the initiation of DNA replication in eukaryotes are: (1) Does DNA synthesis begin at a defined place? (2) What determines replication initiation sites? (3) What regulates an origin to fire only once per cell cycle?
Susan A, Gerbi, Zaklina, Strezoska, John M, Waggener   +2 more
openaire   +4 more sources

Initiation of archaeal DNA replication

Biochemical Society Transactions, 2003
The identification of DNA as the genetic material and the elucidation of its structure by Watson and Crick [Watson and Crick, (1953) Nature (London) 171, 737–738], which has its 50th anniversary this year, first suggested the simple elegance with which the problem of passing on precise genetic information from one generation to the next could be solved.
E R, Jenkinson, J P J, Chong
openaire   +2 more sources

REGULATION OF INITIATION OF DNA REPLICATION

Annual Review of Genetics, 1979
INTRODUCTION 355 UNIQUENESS OF THE SITE OF INITIATION OF REPLICATION 357 STRUCTURE OF THE ORIGIN SITE 359 EVENTS AT THE INITIATION SITE . . . . 362 TRANSCRIPTIONAL ACTIVATION 365 DIRECTIONALITY OF REPLICATION 366 HOST FUNCTIONS REQUIRED FOR INITIATION 367 REPLICON-SPECIFIC INITIATION PROTEINS . . . . . . . . . . ...... ....... ....... .
R, Kolter, D R, Helinski
openaire   +2 more sources

Initiation of adenovirus DNA replication

Journal of Virology, 1980
In an attempt to study the mechanism of initiation of adenovirus DNA replication, an assay was developed to investigate the pattern of DNA synthesis in early replicative intermediates of adenovirus DNA. By using wild-type virus-infected cells, it was possible to place the origin of adenovirus type 2 DNA replication within the terminal 350 to 500 base ...
T, Reiter, J, Fütterer, B, Weingärtner, E L, Winnacker   +3 more
openaire   +2 more sources

Initiation of Viral DNA Replication

1988
Publisher Summary This chapter focuses on the mechanisms involved in initiation of animal virus DNA replication. This step is of fundamental importance because it represents the central point of control of the replication process. Two of the best-characterized viruses, adenovirus and SV40, are discussed as examples of viruses that normally multiply ...
T J, Kelly, M S, Wold, J, Li
openaire   +2 more sources

Chromatin remodeling and initiation of DNA replication

Frontiers in Bioscience, 2001
While much has been learned in recent years about the process of chromatin remodeling and its role in activation of transcription, relatively little has been reported on the role of chromatin remodeling in DNA replication. However, it is well established that transcription factors and chromatin structure play an important role in replication origin ...
T, Melendy, R, Li
openaire   +2 more sources

DNA Replication Initiation

2009
DNA replication is fundamental to cellular life on earth, and replication initiation provides the primary point of control over this process. Replication initiation in all organisms involves the interaction of initiator proteins with one or more origins of replication in the DNA, with subsequent regulated assembly of two replisome complexes at each ...
openaire   +2 more sources