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Initiation of DNA Replication in the Archaea
2017Organisms within the archaeal domain of life possess a simplified version of the eukaryotic DNA replication machinery. While some archaea possess a bacterial-like mode of DNA replication with single origins of replication per chromosome, the majority of species characterized to date possess chromosomes with multiple replication origins.
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A turnstile for initiation of DNA replication
Trends in Cell Biology, 1991The progress of a cell through its growth cycle is a multifaceted process; so far we have seen only a glimpse of the complex interplay between the macromolecules performing and regulating the different steps involved. In most organisms, control mechanisms ensure that all chromosomal DNA sequences are replicated once, and only once, between two cell ...
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INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS
Annual Review of Cell and Developmental Biology, 1997▪ Abstract The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur
A, Dutta, S P, Bell
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Initiation of eukaryotic DNA replication in vitro
BioEssays, 1988AbstractRecent advances in our understanding of the mechanism and regulation of eukaryotic DNA replication have been expedited by the use of cell‐free systems capable of initiation of DNA replication. The system capable of replicating plasmid DNAs containing the SV40 origin of DNA replication in vitro is a paradigm for studies on the replication of ...
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AAA+ ATPases in the Initiation of DNA Replication
Critical Reviews in Biochemistry and Molecular Biology, 2008All cellular organisms and many viruses rely on large, multi-subunit molecular machines, termed replisomes, to ensure that genetic material is accurately duplicated for transmission from one generation to the next. Replisome assembly is facilitated by dedicated initiator proteins, which serve to both recognize replication origins and recruit requisite ...
Karl E, Duderstadt, James M, Berger
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Epigenetic landscape for initiation of DNA replication
Chromosoma, 2013The key genetic process of DNA replication is initiated at specific sites referred to as replication origins. In eukaryotes, origins of DNA replication are not specified by a defined nucleotide sequence. Recent studies have shown that the structural context and topology of DNA sequence, chromatin features, and its transcriptional activity play an ...
Vladimir V, Sherstyuk +2 more
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Mechanisms for initiating cellular DNA replication
Science, 2017Diverse molecular choreography of replication Accurate duplication and transmission of genetic information to the next generation requires complex molecular assemblies. Bleichert et al. review replication initiation across the three domains of life, with a focus on origin selection and helicase loading ...
Franziska Bleichert +2 more
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“Replisome”-controlled initiation of DNA replication
Journal of Theoretical Biology, 1971Abstract A model is presented for initiation of DNA replication according to which a membrane-bound structure, the “replisome”, is brought to maturity on a definite region of the bacterial chromosome. Maturation of replisomes is assumed to be a recurrent process the start and the end of which is marked by initiation of DNA replication.
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The Initiation Step of Eukaryotic DNA Replication
2009Eukaryotic initiation of DNA replication is a tightly regulated process. In the yeasts, S-phase-specific cyclin Cdk1 complex as well as Dfb4-Cdc7 kinase phosphorylate the initiation factors Sld2 and Sld3. These factors form a ternary complex with another initiation factor Dbp11 in their phosphorylated state, and associate with the origin of replication.
Pospiech H, Grosse F, Pisani FM
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The initiation of chromosomal DNA replication in eukaryotes
Trends in Genetics, 1990Eukaryotic DNA replication initiates at many sites on each chromosome during the S phase of the cell cycle. Each origin of replication lies in a unique chromosomal environment and can be regulated in different cell types both at the level of utilization and the time of initiation during S phase.
J F, Diffley, B, Stillman
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