Results 221 to 230 of about 390,387 (330)

<i>CYB5R4</i> Gene Methylation as a Potential Epigenetic Marker for Ovarian Cancer. [PDF]

Clin Med Insights Oncol
Gonc A, Sukruoglu Erdogan O, Kilic Erciyas S, Celik Demirbas B, Dinc A, Pasin O, Saip P, Yazici H, Tuncer SB.   +8 more
europepmc   +1 more source

Detection of Restriction Enzyme–Digested Target DNA by PCR Amplification Using a Stem-Loop Primer: Application to the Detection of Hypomethylated Fetal DNA in Maternal Plasma [PDF]

, 2007
Tong Yu, Rossa W. K. Chiu, Tak Yeung Leung, Chunming Ding, Tze Kin Lau, Tse Ngong Leung, YM Dennis Lo   +6 more
openalex   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Cryo-EM structures of DNA-free and DNA-bound BsaXI: architecture of a Type IIB restriction-modification enzyme. [PDF]

Nucleic Acids Res
Shen BW, Heiter D, Yang W, Xu SY, Stoddard BL.   +4 more
europepmc   +1 more source

DNA Sequence Modulates the Conformation of the Food Mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the Recognition Sequence of the NarI Restriction Enzyme^, [PDF]

, 2007
Feng Wang, C. Eric Elmquist, James S. Stover, Carmelo J. Rizzo, Michael P. Stone   +4 more
openalex   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Split-and-pool synthesis to generate scalable combinatorial oligonucleotide libraries on magnetic nanoparticles. [PDF]

STAR Protoc
Nguyen JVL, Malic L, Nassif C, Da Fonte D, Tabrizian M.   +4 more
europepmc   +1 more source

High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires, Ezra Gordon, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond   +4 more
wiley   +1 more source

A snapshot on molecular technologies for diagnosing FAdV infections. [PDF]

Front Vet Sci
Kardoudi A, Siham F, Abdelmounaaim A, Faouzi K, Ikram O, Thomas J, Abdelouaheb B.   +6 more
europepmc   +1 more source

Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization [PDF]

, 2009
Douglas D. Young, Hrvoje Lusic, Mark O. Lively, Alexander Deiters   +3 more
openalex   +1 more source