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DNA sequencing with chain-terminating inhibitors [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1977 A new method for determining nucleotide sequences in DNA is described. It is similar to the "plus and minus" method [Sanger, F. & Coulson, A. R. (1975) J. Mol. Biol.
Frederick Sanger +2 more
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Applications and Challenges of Real-time Mobile DNA Analysis [PDF]
, 2017 The DNA sequencing is the process of identifying the exact order of nucleotides within a given DNA molecule. The new portable and relatively inexpensive DNA sequencers, such as Oxford Nanopore MinION, have the potential to move DNA sequencing outside of ...
Ko, Steven Y. +2 more
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Length-independent DNA packing into nanopore zero-mode waveguides for low-input DNA sequencing [PDF]
Nature Nanotechnology, 2017 Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing exhibits longer read lengths than conventional methods, less GC bias, and the ability to read DNA base modifications.
Henley, Robert Y. +4 more
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The sequence of sequencers: The history of sequencing DNA
Genomics, 2016 Determining the order of nucleic acid residues in biological samples is an integral component of a wide variety of research applications. Over the last fifty years large numbers of researchers have applied themselves to the production of techniques and technologies to facilitate this feat, sequencing DNA and RNA molecules. This time-scale has witnessed
J. Heather, B. Chain
semanticscholar +5 more sources
, 2013 The sequencing of the Human Reference Genome, with Human Genome Project announced ten years ago, provided a roadmap that is the foundation for modern biomedical research.
Can, Mehmet, Gheith, Busra
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Proceedings of the National Academy of Sciences of the United States of America, 1992 The modulation of DNA-protein interactions by methylation of protein-binding sites in DNA and the occurrence in genomic imprinting, X chromosome inactivation, and fragile X syndrome of different methylation patterns in DNA of different chromosomal origin
Marianne Frommer +7 more
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Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: Age-specific N-glycosylation occurs on follicle- stimulating hormone (FSH) in pituitaries of post-menopausal women and results in a higher ratio of fully glycosylated to hypoglycosylated FSH.
Rosemary McDonald +4 more
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DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing
bioRxiv, 2023 Long single-molecular sequencing, such as PacBio circular consensus sequencing (CCS) and nanopore sequencing, is advantageous in detecting DNA 5-methylcytosine (5mC) in CpGs, especially in repetitive genomic regions.
Peng Ni +12 more
semanticscholar +1 more source
Molecular Neurodegeneration, 2021 Background Previous studies have reported that gut microbiota, permeability, short-chain fatty acids (SCFAs), and inflammation are altered in Parkinson’s disease (PD), but how these factors are linked and how they contribute to disease processes and ...
Velma T. E. Aho +9 more
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BMC Genomic Data, 2023 Background Streptococcus pneumoniae (pneumococcus) represents an important human pathogen, responsible for respiratory and invasive infections in the community.
Weronika Puzia +4 more
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