Results 111 to 120 of about 3,677,492 (346)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Reduced plastid genomes of colorless facultative pathogens Prototheca (Chlorophyta) are retained for membrane transport genes

BMC Biology
Background Plastids are usually involved in photosynthesis, but the secondary loss of this function is a widespread phenomenon in various lineages of algae and plants.
Kacper Maciszewski, Gabriela Wilga, Tomasz Jagielski, Zofia Bakuła, Jan Gawor, Robert Gromadka, Anna Karnkowska   +6 more
doaj   +1 more source

Specific termination of RNA polymerase synthesis as a method of RNA and DNA sequencing [PDF]

, 1978
V.D. Axelrod, Robert M. Vartikyan, Vissarion A. Aivazashvili, R. Sh. Beabealashvili   +3 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The use of exonuclease III for preparing single stranded DNA for use as a template in the chain terminator sequencing method [PDF]

, 1979
Andrew J.H. Smith
openalex   +1 more source

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

Nature Communications, 2017
Whole-exome sequencing of cell-free DNA (cfDNA) could enable comprehensive profiling of tumors from blood but the genome-wide concordance between cfDNA and tumor biopsies is uncertain.
V. Adalsteinsson, G. Ha, S. Freeman, A. Choudhury, D. Stover, H. Parsons, G. Gydush, S. Reed, D. Rotem, J. Rhoades, Denis Loginov, D. Livitz, D. Rosebrock, I. Leshchiner, Jaegil Kim, C. Stewart, Mara W Rosenberg, J. Francis, Cheng-Zhong Zhang, Ofir Cohen, Coyin Oh, Huiming Ding, P. Polak, M. Lloyd, Sairah Mahmud, K. Helvie, Margaret S. Merrill, Rebecca A. Santiago, Edward P. O’Connor, Seong H. Jeong, Rachel Leeson, Rachel Barry, J. Kramkowski, Zhenwei Zhang, L. Polacek, Jens G. Lohr, M. Schleicher, Emily Lipscomb, A. Saltzman, Nelly Oliver, L. Marini, Adrienne G. Waks, L. Harshman, S. Tolaney, E. V. Van Allen, Eric P. Winer, N. Lin, M. Nakabayashi, M. Taplin, Cory M. Johannessen, L. Garraway, T. Golub, J. Boehm, N. Wagle, G. Getz, J. C. Love, M. Meyerson   +56 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Determination of the endpoints of partial deletion mutants of the attachment site of bacteriophage lambda by DNA sequencing [PDF]

, 1978
R. Wayne Davies, Peter Schreier, Dagmar E. Büchel   +2 more
openalex   +1 more source

A practical guide to cancer subclonal reconstruction from DNA sequencing

Nature Methods, 2021
M. Tarabichi, A. Salcedo, A. Deshwar, Máire Ní Leathlobhair, J. Wintersinger, D. Wedge, P. Van Loo, Q. Morris, P. Boutros   +8 more
semanticscholar   +1 more source

Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data

Nature Communications, 2019
DNA base modifications, such as C5-methylcytosine (5mC) and N6-methyldeoxyadenosine (6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and long-read PacBio sequencing have inherent limitations to detect DNA ...
Qian Liu, Li Fang, Guoliang Yu, De-Peng Wang, Chuan-Le Xiao, Kai Wang   +5 more
semanticscholar   +1 more source