Results 121 to 130 of about 3,728,691 (365)

Shotgun DNA sequencing using cloned DNase I-generated fragments [PDF]

, 1981
Stephen K. Anderson
openalex   +1 more source

Performance assessment of DNA sequencing platforms in the ABRF Next-Generation Sequencing Study

Nature Biotechnology, 2021
J. Foox, S. Tighe, C. Nicolet, J. Zook, M. Byrska-Bishop, Wayne E. Clarke, Michael M. Khayat, M. Mahmoud, Phoebe K Laaguiby, Zachary T. Herbert, Derek Warner, G. Grills, J. Jen, S. Levy, Jenny Z. Xiang, A. Alonso, Xia Zhao, Wenwei Zhang, Fei Teng, Yonggang Zhao, Haorong Lu, G. Schroth, G. Narzisi, W. Farmerie, F. Sedlazeck, D. Baldwin, C. Mason   +26 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Clinical, immunohistochemical, and genetic characterization of splice-altering biallelic DES variants: Therapeutic implications

HGG Advances
Summary: Pathogenic variants in the DES gene clinically manifest as progressive skeletal muscle weakness, cardiomyopathy with associated severe arrhythmias, and respiratory insufficiency, and are collectively known as desminopathies.
Janelle Geist Hauserman, Chamindra G. Laverty, Sandra Donkervoort, Ying Hu, Sarah Silverstein, Sarah B. Neuhaus, Dimah Saade, Gabrielle Vaughn, Denise Malicki, Rupleen Kaur, Yuesheng Li, Yan Luo, Poching Liu, Patrick Burr, A. Reghan Foley, Payam Mohassel, Carsten G. Bönnemann   +16 more
doaj   +1 more source

Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors. [PDF]

, 1987
Gerald McMahon, E. A. Davis, Gerald N. Wogan   +2 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencing [PDF]

, 1982
Roger Staden
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Analysis of the genomic termini of tupaia herpesvirus DNA by restriction mapping and nucleotide sequencing [PDF]

, 1985
Marcus W. Albrecht, G. Darai, Rolf M. Flügel   +2 more
openalex   +1 more source

An in vivo patient-derived model of endogenous IDH1-mutant glioma.

Neuro-Oncology, 2012
H. A. Luchman, O. Stechishin, N. Dang, M. Blough, C. Chesnelong, J. Kelly, Stephanie A Nguyen, J. Chan, A. Weljie, J. Cairncross, S. Weiss, Hotchkiss Brain, Institute, Clark H Smith Brain, Dna Sequencing   +14 more
semanticscholar   +1 more source