Results 171 to 180 of about 1,871,571 (343)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

A graph theoretic approach to the analysis of DNA sequencing data. [PDF]

, 1996
Anthony Berno
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells [PDF]

, 2013
Ehsan Habibi, Arie B. Brinkman, Julia Arand, Leonie I. Kroeze, Hindrik H. D. Kerstens, Filomena Matarese, Konstantin Lepikhov, Marta Gut, Isabelle Brun‐Heath, Nina C. Hubner, Rosaria Benedetti, Lucia Altucci, Joop H. Jansen, Jörn Walter, Marta Gut, Hendrik Marks, H.G. Stunnenberg   +16 more
openalex   +1 more source

Identification of SARS-CoV-2 Polymerase and Exonuclease Inhibitors and Novel Methods for Single-Color Fluorescent DNA Sequencing by Synthesis

, 2021
Xuanting Wang
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Focused Size Selection of Cell-Free DNA Samples for Liquid Biopsy Applications that Rely on Next-Generation Sequencing

, 2019
Christopher K. Raymond
openalex   +1 more source

End-repair causes methylation underestimation in cell-free DNA sequencing libraries. [PDF]

J Liq Biopsy
Groth TE, Mishin AA, Rao V, Tibet R, Troll CJ.   +4 more
europepmc   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

SMAdd-seq: probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing [PDF]

Gali Bai, Namrita Dhillon, Colette Felton, Brett Meissner, Brandon Saint-John, Robert Shelansky, Elliot Meyerson, Eva Hrabeta‐Robinson, Babak Hodjat, Hinrich Boeger, Angela N. Brooks   +10 more
openalex   +1 more source