Results 241 to 250 of about 1,871,571 (343)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age [PDF]

Bowen Zhu, Dean Li, Guojing Han, Yao Xue, Heng Gu, Tao Liu, Linghua Liu, Jie Dai, Isabella Liu, Yunshi Liang, Jian Zheng, Zhijun Sun, Lin He, Nan Liu, Haidong Yu, Meifang Shi, G. F. Shen, Zhaohui Hu, Lefeng Qu   +18 more
openalex   +1 more source

Utility of microbial cell-free DNA sequencing in the diagnosis of mycobacterial infections in a quaternary care center. [PDF]

Antimicrob Steward Healthc Epidemiol
Centeno FH, Lasco T, Hamdi AM, Al Mohajer M.   +3 more
europepmc   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

DNA Sequencing [PDF]

, 2019
openaire   +1 more source

DelSIEVE: cell phylogeny modeling of single nucleotide variants and deletions from single-cell DNA sequencing data. [PDF]

Genome Biol
Kang S, Borgsmüller N, Valecha M, Markowska M, Kuipers J, Beerenwinkel N, Posada D, Szczurek E.   +7 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Author Correction: DNA sequencing at the picogram level to investigate life on Mars and Earth. [PDF]

Sci Rep
Raghavendra JB, Zorzano MP, Kumaresan D, Martin-Torres J.   +3 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Long-read DNA sequencing reveals the organization of the mitochondrial genome in the early-branching dinoflagellate Oxyrrhis marina.

Ronie Haro, Nikita Walunjkar, Soham Jorapur, Claudio H. Slamovits   +3 more
openalex   +1 more source