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Tracking DNA Synthesis with Single-Molecule Strand Displacement
The Journal of Physical Chemistry B, 2018We have previously shown that double-stranded DNA labeled with a periodic series of fluorescent dyes can be used to track a single helicase. Here we demonstrate how this technique can be adapted to follow processive DNA synthesis. By monitoring strand displacement, we track the motion of a single ϕ29 DNA polymerase without labeling or altering the ...
Charles E. Wickersham, Everett A. Lipman
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Dynamic protein assembly by programmable DNA strand displacement
Nature Chemistry, 2018Inspired by the remarkable ability of natural protein switches to sense and respond to a wide range of environmental queues, here we report a strategy to engineer synthetic protein switches by using DNA strand displacement to dynamically organize proteins with highly diverse and complex logic gate architectures. We show that DNA strand displacement can
Rebecca P. Chen +3 more
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Chaperone‐Polymer‐Assisted, Photodriven DNA Strand Displacement
ChemBioChem, 2017AbstractPhotodriven DNA strand displacement by using a 2′,6′‐dimethylazobenzene‐tethered strand and poly(l‐lysine)‐graft‐dextran (PLL‐g‐Dex) as a chaperone is reported. Rapid strand displacement was reversibly induced by UV and visible‐light irradiation without any toehold portion.
Bohao Cheng +4 more
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DNA strand displacement system running logic programs
Biosystems, 2014The paper presents a DNA-based computing model which is enzyme-free and autonomous, not requiring a human intervention during the computation. The model is able to perform iterated resolution steps with logical formulae in conjunctive normal form. The implementation is based on the technique of DNA strand displacement, with each clause encoded in a ...
Alfonso Rodríguez-Patón +2 more
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Neural network computation with DNA strand displacement cascades
Nature, 2011The impressive capabilities of the mammalian brain--ranging from perception, pattern recognition and memory formation to decision making and motor activity control--have inspired their re-creation in a wide range of artificial intelligence systems for applications such as face recognition, anomaly detection, medical diagnosis and robotic vehicle ...
Lulu Qian, Erik Winfree, Jehoshua Bruck
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Dynamic DNA Strand Displacement Circuits
2010Nucleic acids, the "NA" in DNA and RNA, have long been known to be vitally important molecules within biological cells and organisms. However, they are interesting for more than just their known roles in biology: their predictable Watson-Crick base pairing properties allow nucleic acids to be powerful nanoscale engineering tools.
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Cooperative Branch Migration: A Mechanism for Flexible Control of DNA Strand Displacement
ACS Nano, 2022, , Ting Wang
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Kinetics of RNA and RNA:DNA Hybrid Strand Displacement
ACS Synthetic Biology, 2021Hao Yan, Thomas Ouldridge, Junyi Che
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Encryption Algorithm Based on DNA Strand Displacement and DNA Sequence Operation
IEEE Transactions on Nanobioscience, 2021Shuang Zhou +2 more
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A Responsive Hidden Toehold To Enable Controllable DNA Strand Displacement Reactions
Angewandte Chemie - International Edition, 2011Dongsheng Liu, Yongzheng Xing
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