Results 231 to 240 of about 2,195,182 (275)

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

Dissipative Control Over the Toehold-Mediated DNA Strand Displacement Reaction [PDF]

Angewandte Chemie - International Edition, 2022
Here we show a general approach to achieve dissipative control over toehold-mediated strand-displacement, the most widely employed reaction in the field of DNA nanotechnology.
Leonard J Prins, Ralf Seidel, Francesco Ricci   +2 more
exaly   +6 more sources

DNA Replication Through Strand Displacement During Lagging Strand DNA Synthesis in Saccharomyces cerevisiae [PDF]

Genes, 2019
This review discusses a set of experimental results that support the existence of extended strand displacement events during budding yeast lagging strand DNA synthesis.
Michele Giannattasio, Dana Branzei
exaly   +6 more sources

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Multifunctional Clip Strand for the Regulation of DNA Strand Displacement and Construction of Complex DNA Nanodevices

ACS Nano, 2021
Strand displacement reactions are important bricks for the construction of various DNA nanodevices, among which the toehold-mediated strand displacement reaction is the most prevalently adopted. However, only a limited number of tools could be used to finely regulate the toehold reaction, thus restricting DNA nanodevices from being more multifunctional
Hongbo Wang, Longjie Li, Zhihao Ming
exaly   +3 more sources

Biocomputing Based on DNA Strand Displacement Reactions

ChemPhysChem, 2021
AbstractThe high sequence specificity and precise base complementary pairing principle of DNA provides a rich orthogonal molecular library for molecular programming, making it one of the most promising materials for developing bio‐compatible intelligence. In recent years, DNA has been extensively studied and applied in the field of biological computing.
Qian Li, Chunhai Fan, Jiye Shi
exaly   +3 more sources

The neuronal perceptron with DNA strand displacement

2018 Tenth International Conference on Advanced Computational Intelligence (ICACI), 2018
In the field of biologic computing and neural networks, DNA strand displacement technology performs well in computing, programming and information processing. In this paper, based on two-domain DNA strand displacement, the neural DNA perceptron is proposed to implement Boolean operations. Some operation instances are simulated by Visual DSD (DNA strand
Lanlan Shi, Changjun Zhou, Qiang Zhang 0008   +2 more
openaire   +1 more source

Heterochiral DNA Strand-Displacement Circuits

Journal of the American Chemical Society, 2017
The absence of a straightforward strategy to interface native d-DNA with its enantiomer l-DNA-oligonucleotides of opposite chirality are incapable of forming contiguous Watson-Crick base pairs with each other-has enforced a "homochiral" paradigm over the field of dynamic DNA nanotechnology.
Adam M. Kabza, Brian E. Young, Jonathan T. Sczepanski   +2 more
openaire   +2 more sources