Results 241 to 250 of about 2,195,182 (275)

DNA Strand-Displacement Timer Circuits

ACS Synthetic Biology, 2016
Chemical circuits can coordinate elaborate sequences of events in cells and tissues, from the self-assembly of biological complexes to the sequence of embryonic development. However, autonomously directing the timing of events in synthetic systems using chemical signals remains challenging.
Joshua, Fern, Dominic, Scalise, Angelo, Cangialosi, Dylan, Howie, Leo, Potters, Rebecca, Schulman   +5 more
openaire   +2 more sources

Performing DNA Strand Displacement with DNA Polymerase

2020
Significant improvements to the dynamic DNA nano science have emerged in recent years, primarily due to the elaborate design of toehold-mediated DNA strand displacement (TMSD). However, it remains an ongoing challenge to design huge-scaled TMSD based sophisticated dynamic DNA structures without base-pair mismatching or unwanted secondary structures ...
Zhiyu Wang, Yingxin Hu, Zhekun Chen, Sulin Liao, Yabing Huang   +4 more
openaire   +1 more source

Analog Computation by DNA Strand Displacement Circuits

ACS Synthetic Biology, 2016
DNA circuits have been widely used to develop biological computing devices because of their high programmability and versatility. Here, we propose an architecture for the systematic construction of DNA circuits for analog computation based on DNA strand displacement.
Tianqi, Song, Sudhanshu, Garg, Reem, Mokhtar, Hieu, Bui, John, Reif   +4 more
openaire   +2 more sources

Circular DNA Logic Gates with Strand Displacement

Langmuir, 2009
Circular DNA logic gates were constructed on the basis of DNA three-way branch migration. In this logic system, circular DNA was used as a basic work unit and linear single-strand DNA was used as input and output signals. Making use of the circular structure, most of the DNA-specific recognition regions were designed in a single DNA ring.
Cheng, Zhang, Jing, Yang, Jin, Xu
openaire   +2 more sources

Connecting localized DNA strand displacement reactions

Nanoscale, 2015
Design and characterization of a DNA-based localized amplification circuit which, upon tethering on a DNA origami platform, greatly accelerates the catalytic response.
Mullor Ruiz, Ismael, Arbona, Jean-Michel, Lad, Amitkumar, Mendoza, Oscar, Aimé, Jean-Pierre, Elezgaray, Juan   +5 more
openaire   +3 more sources

Autonomous Resolution Based on DNA Strand Displacement

2011
We present a computing model based on the technique of DNA strand displacement which performs a chain of logical resolutions with logical formulae in conjunctive normal form. The model is enzymefree and autonomous. Each clause of a formula is encoded in a separate DNA molecule: propositions are encoded assigning a strand to each proposition p, and its ...
Alfonso Rodríguez-Patón, Iñaki Sainz de Murieta, Petr Sosík   +2 more
openaire   +1 more source

Robustness of Localized DNA Strand Displacement Cascades

ACS Nano, 2014
Abstract Colocalization can strongly alter the kinetics and efficiency of chemical processes. For instance, in DNA-templated synthesis unfavorable reactions are sped up by placing reactants into close proximity onto a DNA scaffold. In biochemistry, clustering of enzymes has been demonstrated to enhance the reaction flux through some ...
Mario, Teichmann, Enzo, Kopperger, Friedrich C, Simmel   +2 more
openaire   +2 more sources

Strand Displacement Increases the Fidelity of DNA Polymerases

Biochemistry
Fidelity of DNA polymerases, defined as their ability to incorporate a correct dNMP opposite an undamaged template nucleotide, is a key factor in ensuring genome stability. Many DNA polymerases have been extensively investigated to understand the structural and biochemical basis of their fidelity.
Anna V. Yudkina, Alexander O. Yakovlev, Denis A. Rychkov, Victor M. Golyshev, Dmitry O. Zharkov   +4 more
openaire   +2 more sources

Mechanism of DNA multimerization caused by strand-displacement DNA polymerases

Analytical Biochemistry
It has been recently shown that for Bst DNA polymerase, the side isothermal amplification reaction named multimerization (MM) proceeds under certain conditions. MM hinders interpretation of amplification results and reduces the accuracy and reliability of DNA/RNA diagnostics.
Assol R. Sakhabutdinova, Ravil R. Garafutdinov   +1 more
openaire   +2 more sources

Base Conversion Model Based on DNA Strand Displacement

2020
DNA computing has the advantages of high parallelism and large storage. In this paper, DNA strand displacement techniques are applied to binary to decimal system. In the field of DNA calculation, binary numerical calculation is relatively mature, but it is difficult to implement decimal calculation.
Zhao Chen, Zhixiang Yin, Jianzhong Cui, Zhen Tang, Qiang Zhang 0008   +4 more
openaire   +2 more sources