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DNA strand displacement system running logic programs

Biosystems, 2014
The paper presents a DNA-based computing model which is enzyme-free and autonomous, not requiring a human intervention during the computation. The model is able to perform iterated resolution steps with logical formulae in conjunctive normal form. The implementation is based on the technique of DNA strand displacement, with each clause encoded in a ...
Alfonso Rodríguez-Patón   +2 more
openaire   +2 more sources

Dynamic DNA nanotechnology using strand-displacement reactions

Nature Chemistry, 2011
The specificity and predictability of Watson-Crick base pairing make DNA a powerful and versatile material for engineering at the nanoscale. This has enabled the construction of a diverse and rapidly growing set of DNA nanostructures and nanodevices through the programmed hybridization of complementary strands.
David Yu, Zhang, Georg, Seelig
openaire   +2 more sources

Tracking DNA Synthesis with Single-Molecule Strand Displacement

The Journal of Physical Chemistry B, 2018
We have previously shown that double-stranded DNA labeled with a periodic series of fluorescent dyes can be used to track a single helicase. Here we demonstrate how this technique can be adapted to follow processive DNA synthesis. By monitoring strand displacement, we track the motion of a single ϕ29 DNA polymerase without labeling or altering the ...
Charles E. Wickersham, Everett A. Lipman
openaire   +2 more sources

Dynamic protein assembly by programmable DNA strand displacement

Nature Chemistry, 2018
Inspired by the remarkable ability of natural protein switches to sense and respond to a wide range of environmental queues, here we report a strategy to engineer synthetic protein switches by using DNA strand displacement to dynamically organize proteins with highly diverse and complex logic gate architectures. We show that DNA strand displacement can
Rebecca P. Chen   +3 more
openaire   +2 more sources

Chaperone‐Polymer‐Assisted, Photodriven DNA Strand Displacement

ChemBioChem, 2017
AbstractPhotodriven DNA strand displacement by using a 2′,6′‐dimethylazobenzene‐tethered strand and poly(l‐lysine)‐graft‐dextran (PLL‐g‐Dex) as a chaperone is reported. Rapid strand displacement was reversibly induced by UV and visible‐light irradiation without any toehold portion.
Bohao Cheng   +4 more
openaire   +2 more sources

Neural network computation with DNA strand displacement cascades

Nature, 2011
The impressive capabilities of the mammalian brain--ranging from perception, pattern recognition and memory formation to decision making and motor activity control--have inspired their re-creation in a wide range of artificial intelligence systems for applications such as face recognition, anomaly detection, medical diagnosis and robotic vehicle ...
Lulu Qian, Erik Winfree, Jehoshua Bruck
openaire   +3 more sources

Dynamic DNA Strand Displacement Circuits

2010
Nucleic acids, the "NA" in DNA and RNA, have long been known to be vitally important molecules within biological cells and organisms. However, they are interesting for more than just their known roles in biology: their predictable Watson-Crick base pairing properties allow nucleic acids to be powerful nanoscale engineering tools.
openaire   +1 more source

Therapeutics and DNA Methylation Inhibitors

Medical Epigenetics, 2021
Shyamala C Navada
exaly  

Encryption Algorithm Based on DNA Strand Displacement and DNA Sequence Operation

IEEE Transactions on Nanobioscience, 2021
Shuang Zhou, Chengye Zou, Changjun Zhou
exaly  

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