Results 151 to 160 of about 115,106 (246)

Cardenolide‐Engineered Extracellular Vesicles Augment Drug Uptake and Cytotoxicity in Non‐small Cell Lung Cancer Cells

Small Methods, Volume 10, Issue 3, 9 February 2026.
Cardenolide‐functionalized extracellular vesicles enable targeted delivery of the chemotherapeutic doxorubicin to A549 lung cancer cells by binding Na+/K+‐ATPase, which is overexpressed in these cells. Surface‐modified, drug‐loaded EVs exhibit enhanced cytotoxicity compared to unmodified EVs and free drug, suggesting this system may lower the effective
Maja Dorfner, Anika Mifka, Rodrigo Maia de Pádua, Izabella Thaís da Silva, Iara Zanella Guterres, Lorenzo Sana, Gregor Fuhrmann, Jennifer Munkert   +7 more
wiley   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, Volume 7, Issue 1, February 2026.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Previously Uncharacterised Aliphatic Amino Acid Positions Modulate the Apparent Catalytic Activity of the EAL Domain of ZMO_1055 and Other Cyclic Di‐GMP‐Specific EAL Phosphodiesterases

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
The A526V substitution, previously not recognised to affect the functionality of the EAL domain, downregulates the apparent catalytic activity of the PAS‐GGDEF‐EAL ZMO1055 phosphodiesterase and other GGDEF‐EAL proteins. Substitution of A526, which is conserved among homologues, with amino acids with longer aliphatic side chains than valine, reverts to ...
Lian‐Ying Cao, Xue Zhang, Feng‐wu Bai, Ute Römling   +3 more
wiley   +1 more source

Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs. [PDF]

Genes Cells
Sakasai R, Iwabuchi K.
europepmc   +1 more source

Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells. [PDF]

Oncotarget, 2023
Juchem ALM, Trindade C, da Silva JB, Machado MDS, Guecheva TN, Rocha JC, Saffi J, de Oliveira IM, Henriques JAP, Escargueil A.   +9 more
europepmc   +1 more source

Identification of prokineticin‐2 as potential pharmacodynamic biomarker for overcoming doxorubicin resistance in multicellular breast cancer spheroids

British Journal of Pharmacology, Volume 183, Issue 3, Page 491-504, February 2026.
Background and purpose Despite advances in immunotherapy, doxorubicin (Dox) chemotherapy is still the irreplaceable first‐line therapy for solid tumours such as breast cancer. However, chemotherapy resistance is the major limiting factor, requiring the use of high doses of Dox to achieve the anti‐tumour actions, often leading to severe side effects ...
Martina Vincenzi, Amin Kremic, Nathalie N. Tscheiller, Po‐Yen Hsu, Michael W. Y. Chan, Roberta Lattanzi, Canan G. Nebigil   +6 more
wiley   +1 more source

Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1. [PDF]

Proc Natl Acad Sci U S A
Tumini E, Wellinger RE, Herrera-Moyano E, Navarro-Cansino P, García-Rubio M, Salas-Lloret D, Losada A, Muñoz-Alonso MJ, Gaillard H, Luna R, Aguilera A.   +10 more
europepmc   +1 more source

Regulation of R‐Loop Dynamics by Proteins and Long Noncoding RNAs: An Emerging Paradigm for Cancer Treatment

Cancer Science, Volume 117, Issue 2, Page 297-307, February 2026.
R‐loops are three‐stranded nucleic acid structures whose dysregulation leads to genomic instability and cancer progression. This review summarizes the protein and lncRNA machineries that regulate R‐loop dynamics and discusses the therapeutic potential of targeting these pathways in cancer.
Miho M. Suzuki, Keiko Shinjo, Tatsunori Nishimura, Yutaka Kondo   +3 more
wiley   +1 more source

Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties. [PDF]

J Enzyme Inhib Med Chem, 2023
Kaproń B, Płazińska A, Płaziński W, Plech T.   +3 more
europepmc   +1 more source

Global diversification of coastal Cafius rove beetles (Coleoptera: Staphylinidae) driven by ocean currents since the early Miocene

Cladistics, Volume 42, Issue 1, Page 79-94, February 2026.
Abstract As our understanding of abiotic factors continues to grow, along with insights into the biological traits of organisms, so too does the sophistication of studies exploring global diversification and spatio‐temporal distribution patterns. The global distribution of coastal Cafius rove beetles, combined with the endemic distribution patterns ...
Kee‐Jeong Ahn, Jeong‐Hun Song
wiley   +1 more source