Results 161 to 170 of about 113,306 (267)

The SWIB domain-containing DNA topoisomerase I of <i>Chlamydia trachomatis</i> mediates DNA relaxation. [PDF]

J Bacteriol
Shen L, Swoboda AR, Diggs C, Ferdous S, Terrebonne A, Santos A, Wolf N, Lorenzo Carvajal L, Zhong G, Ouellette SP, Tse-Dinh Y-C.   +10 more
europepmc   +1 more source

Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties. [PDF]

J Enzyme Inhib Med Chem, 2023
Kaproń B, Płazińska A, Płaziński W, Plech T.   +3 more
europepmc   +1 more source

Characterization of a prokaryotic topoisomerase I activity in chloroplast extracts of maize [PDF]

, 1983
Siedlecki, Janusz, Weissbach, Arthur, Zimmermann, Wolfgang   +2 more
core  

Elucidating the Solvent‐Dependent Solvation and Structural Stability of Irinotecan: A Molecular Simulation Study

ChemPhysChem, Volume 27, Issue 8, 28 April 2026.
The solvation preference of irinotecan is governed by a competition between cavity formation and electrostatic stabilization. Computations reveal that the high cost of breaking water's hydrogen bond network outweighs its electrostatic benefits. In contrast, polar aprotic solvents (e.g., pyridine) offer an optimal thermodynamic balance, providing strong
Martin M. Bitabo, Sixberth Mlowe, Daniel M. Shadrack, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Targeting DNA Topoisomerase IIα in Retinoblastoma: Implications in EMT and Therapeutic Strategies. [PDF]

Biologics
Wei Q, Lin N, Wang L.
europepmc   +1 more source

Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα. [PDF]

Pharmaceuticals (Basel), 2023
Cvijetić IN, Herlah B, Marinković A, Perdih A, Bjelogrlić SK.   +4 more
europepmc   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Exploring DNA topoisomerase II alpha in adrenocortical carcinoma through multi-omics analysis: a potential biomarker and therapeutic target. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Lu J, Deng P, Wu Z, Liang Y, Zhuo Y, Wu Y, Liang Y, Ye J, Xie W, Cai Z, Cai C, Chen J, Zhang L, Deng J, Zhong W, Tang J, Han Z.   +16 more
europepmc   +1 more source

A RADAR method to measure DNA topoisomerase covalent complexes. [PDF]

Methods Enzymol, 2022
Meroni A, Vindigni A.
europepmc   +1 more source

Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor. [PDF]

Cell Rep Med
Wang R, Fang P, Chen X, Ji J, Yu D, Mei F, Wang Z, Zhou W, Peng W, Wang R, Wang J, Guo C, Wu H, Liu D, Tan X, Gui X.   +15 more
europepmc   +1 more source