Results 171 to 180 of about 1,521,597 (298)

Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα. [PDF]

Pharmaceuticals (Basel), 2023
Cvijetić IN, Herlah B, Marinković A, Perdih A, Bjelogrlić SK.   +4 more
europepmc   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

A RADAR method to measure DNA topoisomerase covalent complexes. [PDF]

Methods Enzymol, 2022
Meroni A, Vindigni A.
europepmc   +1 more source

Doxorubicin and 4‐Hydroperoxycyclophosphamide Alter Mitochondrial Dynamics and miR‐34 Expression in Spermatogonia and Spermatocytes In Vitro

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Doxorubicin (DOX) and cyclophosphamide (CP) are widely used chemotherapeutic agents with known gonadotoxic effects. Since miRNAs play a key role in the transcriptional regulation of spermatogenesis, they are suggested as biomarkers for male infertility.
Hülya Öztatlıcı, Mahmut Kemal Özbilgin, Rukiye Betül Çolaksel, Suna Karadeniz Saygılı, Mustafa Öztatlıcı   +4 more
wiley   +1 more source

Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties. [PDF]

J Enzyme Inhib Med Chem, 2023
Kaproń B, Płazińska A, Płaziński W, Plech T.   +3 more
europepmc   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

The SWIB domain-containing DNA topoisomerase I of <i>Chlamydia trachomatis</i> mediates DNA relaxation. [PDF]

J Bacteriol
Shen L, Swoboda AR, Diggs C, Ferdous S, Terrebonne A, Santos A, Wolf N, Lorenzo Carvajal L, Zhong G, Ouellette SP, Tse-Dinh Y-C.   +10 more
europepmc   +1 more source

Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications

International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 961-971, October 2026.
ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du, Shunsuke Koga, Guang Yang, Saar Gill, Adam Bagg   +4 more
wiley   +1 more source

Targeting DNA Topoisomerase IIα in Retinoblastoma: Implications in EMT and Therapeutic Strategies. [PDF]

Biologics
Wei Q, Lin N, Wang L.
europepmc   +1 more source

Autoantibodies against DNA topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses. [PDF]

Am J Transplant, 2023
Gorbacheva V, Fan R, Miyairi S, Fairchild RL, Baldwin WM, Valujskikh A.   +5 more
europepmc   +1 more source