Results 151 to 160 of about 1,521,597 (298)

Topoisomerase IIα C-terminus DNA Purification

, 2018
As humans, it is essential that our cells replicate as we about our lives. This occurs through DNA replication, which is a process that is dependent upon the topoisomerase enzyme.
Toma, Maryo
core   +1 more source

Dataset from Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1

Numerical data used to generate graphs in the manuscript "Patulin and Xestoquinol are inhibitors of DNA topoisomerase 1"Peer ...
Losada, Alejandro, Wellinger, Ralf Erik, Herrera-Moyano, Emilia, Salas-Lloret, Daniel, Gaillard, Hélène, Tumini, Emanuela, Aguilera, Andrés, García-Rubio, María, Luna, Rosa, Navarro-Cansino, Patricia, Muñoz-Alonso, María J.   +10 more
core   +1 more source

Expression of Topoisomerase II Alpha in Canine Colorectal Polyps, Adenomas and Adenocarcinomas

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT With the development and increased accessibility of diagnostic methods in veterinary medicine, the possibilities for early detection of proliferative lesions in the canine large intestine have expanded over the past decade. Since in human medicine, topoisomerase II alpha (Topo IIα) is considered a prognostic and predictive marker in various ...
Joanna Fiedorowicz, Katarzyna Paździor‐Czapula, Paweł Antoni Kołodziejski, Iwona Otrocka‐Domagała   +3 more
wiley   +1 more source

Discovery of Bis-Thiourea Derivatives as Human DNA Topoisomerase IIα Inhibitors with Potent Anticancer Effects. [PDF]

ACS Omega
Sabuakham S, Kitdumrongthum S, Nasoontorn S, Monmai C, Talabnin C, Araki N, Silsirivanit A, Rungrotmongkol T, Chairoungdua A, Pingaew R, Mahalapbutr P.   +10 more
europepmc   +1 more source

Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in Streptococcus pneumoniae. [PDF]

Int J Mol Sci, 2023
García-López M, Hernández P, Megias D, Ferrándiz MJ, Campa AG.   +4 more
europepmc   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Arginine methylation of human DNA topoisomerase I by PRMT5 facilitates DNA relaxation. [PDF]

Nucleic Acids Res
Basu S, Bhattacharyya A, Khan MA, Pal U, Chowdhuri SP, Satrusal SR, Baranello L, Datta D, Das BB.   +8 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs. [PDF]

Genes Cells
Sakasai R, Iwabuchi K.
europepmc   +1 more source

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription. [PDF]

Nat Commun, 2023
Lau MS, Hu Z, Zhao X, Tan YS, Liu J, Huang H, Yeo CJ, Leong HF, Grinchuk OV, Chan JK, Yan J, Tee WW.   +11 more
europepmc   +1 more source