Results 201 to 210 of about 115,106 (246)

DNA topoisomerase II inhibition potentiates osimertinib's therapeutic efficacy in EGFR-mutant non-small cell lung cancer models. [PDF]

J Clin Invest
Chen Z, Vallega KA, Wang D, Quan Z, Fan S, Wang Q, Leal T, Ramalingam SS, Sun SY.   +8 more
europepmc   +1 more source

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models. [PDF]

J Transl Med
Lin S, Zhang Y, Yao J, Yang J, Qiu Y, Zhu Z, Hua H.   +6 more
europepmc   +1 more source

Targeted repression of topA by CRISPRi reveals a critical function for balanced DNA topoisomerase I activity in the Chlamydia trachomatis developmental cycle. [PDF]

mBio
Shen L, Gao L, Swoboda AR, Ouellette SP.
europepmc   +1 more source

Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models. [PDF]

Mol Cancer Ther
Suzuki H, Nagase S, Saito C, Takatsuka A, Nagata M, Honda K, Kaneda Y, Nishiya Y, Honda T, Ishizaka T, Nakamura K, Nakada T, Abe Y, Agatsuma T.   +13 more
europepmc   +1 more source

DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors. [PDF]

J Transl Med
Li X, Yao J, Qu C, Luo L, Li B, Zhang Y, Zhu Z, Qiu Y, Hua H.   +8 more
europepmc   +1 more source

DNA topoisomerase I acts as supercoiling sensor for transcription elongation inE. coli

Vidmar V, Borde C, Bruno L, Takacs M, Batisse C, Saint-André C, Zhu C, Espéli O, Lamour V, Weixlbaumer A.   +9 more
europepmc   +1 more source

Correction to 'Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

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DNA Topoisomerases

EcoSal Plus, 2009
DNA topoisomerases are enzymes that control the topological state of DNA in all cells; they have central roles in DNA replication and transcription. They are classified into two types, I and II, depending on whether they catalyze reactions involving the breakage of one or both strands of DNA.
Katherine, Evans-Roberts, Anthony, Maxwell   +1 more
openaire   +3 more sources

DNA topoisomerases

Current Opinion in Structural Biology, 1995
In the past year, the atomic structures of three fragments of type I DNA topoisomerases were elucidated. Together with the atomic structure of a fragment of bacterial gyrase, this wealth of structural information is helping to further our understanding of the mechanism of action of topoisomerases.
A, Sharma, A, Mondragón
openaire   +2 more sources

DNA TOPOISOMERASES

Annual Review of Biochemistry, 1981
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes.
openaire   +6 more sources