Results 221 to 230 of about 113,306 (267)

DNA-topoisomerase inhibitors

Current Opinion in Oncology, 1993
The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
openaire   +1 more source

DNA topoisomerases

Cell, 1980
James C. Wang, Richard I. Gumport, Kashayar Javaherian, Karla Kirkegaard, Leonard Klevan, Michael L. Kotewicz, Yuk-Ching Tse   +6 more
openaire   +3 more sources

DNA topoisomerases

Current Opinion in Cell Biology, 1989
J C, Wang, K, Kirkegaard
openaire   +4 more sources

DNA Topoisomerase Protocols

1999
Assaying DNA Topoisomerase I Relaxation Activity Lance Stewart and James J. Champoux DNA Topoisomerase II-Catalyzed DNA Decatenation Andrea Haldane and Daniel M. Sullivan Plasmid DNA Supercoiling by DNA Gyrase Penny J. Sayer, Martin L. Goble, Mark Oram, and L.
Mary-Ann Bjornsti, Neil Osheroff
openaire   +1 more source

DNA Topoisomerases: Enzymes That Control DNA Conformation

1985
It is common knowledge today that DNA molecules are not simple, rigid double helices, but molecules which have considerable conformational flexibility. This flexibility allows coiling of DNA into complex higher order structures. In most living cells or organelles, including many virus particles, these higher order structures occur on the basis of ...
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Mechanistic Aspects of DNA Topoisomerases

1986
Publisher Summary Topoisomerases are a diverse and important group of enzymes. Although attention has until recently been focused on their ability to interconvert DNA topoisomers, this does not necessarily constitute the primary biological function for all of them.
A, Maxwell, M, Gellert
openaire   +2 more sources

DNA-topoisomerase inhibitors.

Current opinion in oncology, 1994
The topology of DNA is regulated by DNA-topoisomerase enzymes, which induce either transient DNA single-strand breaks (topoisomerase I) or DNA double-strand breaks (topoisomerase II). The action of several anticancer drugs, eg, DNA intercalating agents (ie, anthracyclines, anthracenediones, anthrapyrazoles, amsacrines, and ellipticines) and ...
G, Capranico, G, Giaccone, F, Zunino, S, Garattini, M, D'Incalci   +4 more
openaire   +5 more sources

DNA topoisomerases and topoisomerase inhibitors.

Pathologie-biologie, 1995
DNA topoisomerases are ubiquitous nuclear enzymes, essential for several steps of DNA metabolism. They have recently been shown to be specific targets of a number of anticancer agents. In this review are discussed the most recent discoveries in the physiology and the molecular biology of DNA topoisomerases, and the mechanism of interaction with drugs ...
openaire   +1 more source

[DNA topoisomerase inhibitor].

Nihon rinsho. Japanese journal of clinical medicine, 1994
DNA topoisomerases are enzymes involved in various aspects of genetic processes by catalyzing a topological change of DNA. Topoisomerase is now viewed as an important cellular target of antitumor drugs. These drugs targeting topoisomerase have been used to establish a relationship between drug-induced cleavable complex formation and cytotoxicity ...
M, Hino, H, Niitani
openaire   +1 more source

Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions

Ca-A Cancer Journal for Clinicians, 2021
Michael L Cheng, Heather A Parsons, Atish D Choudhury   +2 more
exaly