Results 211 to 220 of about 1,521,597 (298)

Mapping Meiotic Recombination DNA Double‐Strand Breaks (DSBs) Hotspots —Methodological Advances and Challenges

Advanced Genetics, Volume 7, Issue 3, September 2026.
ABSTRACT Programmed DNA double‐strand breaks (DSBs) initiate meiotic recombination at discrete genomic hotspots, and their precise mapping is crucial for understanding the molecular regulation of genome stability and evolution. A variety of genome‐wide methods have been developed, each leveraging different biochemical principles — from direct capture ...
Jianqiang Bao
wiley   +1 more source

Review and Current Perspectives on DNA Topoisomerase I and II Enzymes of Fungi as Study Models for the Development of New Antifungal Drugs. [PDF]

J Fungi (Basel)
Andrade-Pavón D, Gómez-García O, Villa-Tanaca L.   +2 more
europepmc   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, Volume 3, Issue 3, September 2026.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, Volume 57, Issue 9, Page 1554-1564, September 2026.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Correction to 'Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Computational screening and molecular docking of compounds from Traditional Chinese Medicine (TCM) by targeting DNA topoisomerase I to design potential anticancer drugs. [PDF]

PLoS One
Shimu MSS.
europepmc   +1 more source

Cyclins and Cyclin‐Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer

MedComm, Volume 7, Issue 9, September 2026.
This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng, Zhipeng Shen, Yuanfang Wu, Xingze Huang, Zhongyuan Zhang, Jiangyu Liu, Qichun Wei, Wenhao Chen, Ye Chen, Liang Xu   +9 more
wiley   +1 more source

Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS. [PDF]

Sci Adv
Duardo RC, Marinello J, Russo M, Morelli S, Pepe S, Guerra F, Gómez-González B, Aguilera A, Capranico G.   +8 more
europepmc   +1 more source

Antitumor Activity of Combined Topoisomerase Inhibition and FLASH Radiotherapy in Head and Neck Carcinoma Biomodels

MedComm, Volume 7, Issue 9, September 2026.
We report a proof‐of‐concept combination of topoisomerase inhibition and FLASH radiotherapy showing enhanced antitumor activity in head and neck carcinoma biomodels, supporting further investigation of this strategy in more clinically representative models and treatment settings. ABSTRACT Locally advanced head and neck carcinoma remains associated with
Patrizia Sarogni, Nicoletta Brindani, Valentina Frusca, Melissa Santi, Andrea Cavalieri, Mariagrazia Celentano, Michele Menicagli, Andrea Marranci, Andrea Ghelli Luserna di Rorà, Federico Purificato, Michela Nigro, Noemi Giannini, Alessandra Gonnelli, Giovanni Gadducci, Fabio Di Martino, Fabiola Paiar, Marco De Vivo, Valerio Voliani   +17 more
wiley   +1 more source