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The cleavage of DNA by type-I DNA topoisomerases.
Cold Spring Harbor Symposia on Quantitative Biology, 1984 K. Kirkegaard, G. Pflugfelder, J. Wang
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Journal of Medicinal Chemistry, 2017
DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
G. Capranico +2 more
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DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
G. Capranico +2 more
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Biochemistry of bacterial type I DNA topoisomerases.
Advances in Pharmacology, 1994Y. Tse‐Dinh
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, 1981
Publisher Summary DNA topoisomerases are enzymes that catalyze the breakage and rejoining of DNA strands. The breakage of a DNA backbone bond by a topoisomerase is followed efficiently by the rejoining of the same bond. Therefore, the disjoined state is a transient one and each cycle of breakage and rejoining of a bond is almost invariably detected ...
James C. Wang
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Publisher Summary DNA topoisomerases are enzymes that catalyze the breakage and rejoining of DNA strands. The breakage of a DNA backbone bond by a topoisomerase is followed efficiently by the rejoining of the same bond. Therefore, the disjoined state is a transient one and each cycle of breakage and rejoining of a bond is almost invariably detected ...
James C. Wang
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Future Medicinal Chemistry, 2012
Many anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy.
J. Węsierska-Gądek, A. Składanowski
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Many anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy.
J. Węsierska-Gądek, A. Składanowski
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A DNA topoisomerase type I from wheat embryo mitochondria
Plant Molecular Biology, 1986In order to study DNA replication and expression in wheat mitochondria our laboratory has been seeking to develop a system that supports DNA synthesis and transcription, either in isolated mitochondria from wheat embryos or in a mitochondrial lysate from the same source deprived of endogenous DNA in vitro.
M, Echeverria +3 more
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Stimulation of type I DNA topoisomerase gene expression by pseudorabies virus
Archives of Virology, 1997Previous results from our laboratory have demonstrated that type I DNA topoisomerase activity is required for the replication and gene expression of pseudorabies virus (PRV). In the present report, we further analyzed the expression of topoisomerase I in PRV-infected cells, and the western blot result showed that the expression of topoisomerase I was ...
M L, Wong +4 more
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Type II DNA Topoisomerase from Saccharomyces cerevisiae Is a Stable Dimer
Biochemistry, 1997Type II DNA topoisomerases function as homodimeric enzymes in transiently cleaving double-stranded DNA to catalyze unlinking and unknotting reactions. The dimeric enzyme creates a DNA double-strand break by forming a covalent attachment between an active site tyrosine from each monomer and a 5'-phosphate from each strand of DNA.
R B, Tennyson, J E, Lindsley
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