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Current Opinion in Structural Biology, 1998
Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
J. Berger
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Type II DNA topoisomerases are enzymes capable of passing one DNA duplex through another. A combination of structural and biochemical analyses is illuminating the mechanistic details of this transport reaction, revealing the sites of DNA and nucleotide binding and the existence of large-scale domain motions.
J. Berger
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Alignment and phylogenetic analysis of type II DNA topoisomerases [PDF]
Journal of Biosciences, 1996 DNA topoisomerases have been evolved to solve the topological problems of DNA during replication, transcription, recombination and segregation. Discovery of several new enzymes and their characterization has necessitated this compilation. This analysis shows the distinct evolutionary relatedness of type II DNA topoisomerases.
K. Madhusudan, V. Nagaraja
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Type II DNA topoisomerases in trypanosomatid and apicomplexan parasites
Acta Tropica, 2022Diseases caused by trypanosomatid parasites have no commercially available vaccines for human application. Treatment modalities completely rely on chemotherapeutics strategies that often exhibit clinical drawbacks, like host toxicity, side effects and treatment failure for drug resistance.
Somenath Roy Chowdhury +3 more
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Computational analysis of the chiral action of type II DNA topoisomerases.
Journal of Molecular Biology, 2002It was found recently that bacterial type II DNA topoisomerase, topo IV, is much more efficient in relaxing (+) DNA supercoiling than (-) supercoiling. This means that the DNA-enzyme complex is chiral. This chirality can appear upon binding the first segment that participates in the strand passing reaction (G segment) or only after the second segment ...
K. Klenin, J. Langowski, A. Vologodskii
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Ciprofloxacin: mammalian DNA topoisomerase type II poison in vivo
Mutation Research Letters, 1993Ciprofloxacin (CF), a fluoroquinolone widely used as a potent antimicrobial drug, was evaluated in vivo in mouse bone marrow cells for its ability to induce clastogenicity and DNA damage in terms of increased sister-chromatid exchange (SCE) frequencies.
A, Mukherjee, S, Sen, K, Agarwal
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The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase
Biochemical Pharmacology, 2006Radicicol derivatives are currently investigated as promising antitumoral drugs because they inhibit the activity of the molecular chaperone heat shock protein (HSP90), causing the destabilization and eventual degradation of HSP90 client proteins that are often associated with tumor cells.
Gadelle, D. +2 more
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DNA crossovers and type II DNA topoisomerases: A thermodynamical study.
Journal of molecular biology, 1999We present a theoretical study of the interaction of tight DNA crossovers with eukaryotic type II DNA topoisomerases. A quantitative analysis of the role of the enzyme during anaphase first shows that a tight DNA crossover should be an intermediate of the strand-passage reaction.
J L, Sikorav +3 more
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Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II
Bioorganic & Medicinal Chemistry Letters, 2005DNA topoisomerase (Topo) II is one of the target enzymes for chemotherapeutic drug development. Lanostane-type triterpenoids with various functional groups (-Cl, -Br, -OMe, -CHO, -CN, -COOH, and -COOMe) at C-2 were synthesized from 3-oxolanost-9(11)-en-24S,25-diol (9) isolated from Pinus luchuensis and their inhibitory effects on Topo II activity and ...
Shun-Ichi, Wada, Reiko, Tanaka
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Functional and Regulatory Characteristics of Eukaryotic Type II DNA Topoisomerase
Critical Reviews in Biochemistry and Molecular Biology, 2001DNA topoisomerases are ubiquitous nuclear enzymes that govern the topological interconversions of DNA by transiently breaking/rejoining the phosphodiester backbone of one (type I) or both (type II) strands of the double helix. Consistent with these functions, topoisomerases play key roles in many aspects of DNA metabolism.
Bakshi, RP, Galande, S, Muniyappa, K
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