Results 41 to 50 of about 57,780 (287)
Nucleic Acids Research, 2007 We performed numerical simulations of DNA chains to understand how local geometry of juxtaposed segments in knotted DNA molecules can guide type II DNA topoisomerases to perform very efficient relaxation of DNA knots.
Y. Burnier +3 more
semanticscholar +1 more source
Antibiotics, 2021 Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position and
A. Shaheen +6 more
semanticscholar +1 more source
Conversion of DNA gyrase into a conventional type II topoisomerase [PDF]
Proceedings of the National Academy of Sciences, 1996 DNA gyrase is unique among topoisomerases in its ability to introduce negative supercoils into closed-circular DNA. We have demonstrated that deletion of the C-terminal DNA-binding domain of the A subunit of gyrase gives rise to an enzyme that cannot supercoil DNA but relaxes DNA in an ATP-dependent manner.
Kampranis, S C, Maxwell, A
openaire +2 more sources
Diversity and Functions of Type II Topoisomerases
Acta Naturae, 2021 The DNA double helix provides a simple and elegant way to store and copy genetic information. However, the processes requiring the DNA helix strands separation, such as transcription and replication, induce a topological side-effect – supercoiling of the
Dmitry Sutormin +5 more
semanticscholar +1 more source
Distinct requirements for the Rad32(Mre¹¹) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA [PDF]
, 2009 For a cancer cell to resist treatment with drugs that trap topoisomerases covalently on the DNA, the topoisomerase must be removed. In this study, we provide evidence that the Schizosaccharomyces pombe Rad32Mre11 nuclease activity is involved in the ...
Akamatsu +38 more
core +2 more sources
TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1 [PDF]
, 2012 The abortive activity of topoisomerases can result in clastogenic and/or lethal DNA damage in which the topoisomerase is covalently linked to the 3'- or 5'-terminus of a DNA strand break. This type of DNA damage is implicated in chromosome translocations
Abhishek Sharma +36 more
core +1 more source
1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.
Chemical Research in Toxicology, 2021 1,2-Naphthoquinone, a secondary metabolite of naphthalene, is an environmental pollutant found in diesel exhaust particles that displays cytotoxic and genotoxic properties.
J. A. Collins, N. Osheroff
semanticscholar +1 more source
Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]
, 2015 We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth +12 more
core +2 more sources
Restoration of Topoisomerase 2 Function by Complementation of Defective Monomers in Drosophila [PDF]
, 2014 Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one ...
Geyer, Pamela K. +7 more
core +1 more source
Imatinib enchances the sensitivity of gastrointestinal stromal tumors to topoisomerase II inhibitors
Успехи молекулярной онкологии, 2015 Objective: to study the sensitivity of gastrointestinal stromal tumors (GISTs) to the topoisomerases type II inhibitors and ability of imatinib to enhance GISTs sensitivity to the chemotherapeutic drugs indicated above.Subjects and Methods.
S. V. Boichuk +3 more
doaj +1 more source