Results 71 to 80 of about 57,780 (287)

Updated Review on Clinically-Relevant Properties of Delafloxacin

Antibiotics, 2023
The extensive use of fluoroquinolones has been consequently accompanied by the emergence of bacterial resistance, which triggers the necessity to discover new compounds.
Adrien Turban, François Guérin, Aurélien Dinh, Vincent Cattoir   +3 more
doaj   +1 more source

The Acidic Triad Conserved in Type IA DNA Topoisomerases Is Required for Binding of Mg(II) and Subsequent Conformational Change*

Journal of Biological Chemistry, 2000
The acidic residues Asp-111, Asp-113, and Glu-115 of Escherichia coli DNA topoisomerase I are located near the active site Tyr-319 and are conserved in type IA topoisomerase sequences with counterparts in type IIA DNA topoisomerases.
Chang-Xi Zhu, Y. Tse‐Dinh
semanticscholar   +1 more source

Knotting probabilities after a local strand passage in unknotted self-avoiding polygons

, 2011
We investigate the knotting probability after a local strand passage is performed in an unknotted self-avoiding polygon on the simple cubic lattice.
Bates A, Berg B, Berger J M, Berretti A, Buck G, Burnier Y, C E Soteros, Clisby N, de Carvalho C A, de Carvalho C A, Fishman G S, Fogg J M, Gelman A, Gelman A, Guttmann A J, Hua X, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Liu Z, Liu Z, Liu Z, Liu Z R, M L Szafron, Manturov V, Marcone B, Orlandini E, Orlandini E, Orlandini E, Rybenkov V V, Shaw S Y, Sokal A D, Sumners D W, Szafron M L, Szafron M L, Trigueros S, Vologodskii A, Yan J   +38 more
core   +1 more source

Binding of two DNA molecules by type II topoisomerases for decatenation [PDF]

Nucleic Acids Research, 2012
Topoisomerases (topos) maintain DNA topology and influence DNA transaction processes by catalysing relaxation, supercoiling and decatenation reactions. In the cellular milieu, division of labour between different topos ensures topological homeostasis and control of central processes.
Kumar, Rupesh, Riley, Jane E., Parry, Damian, Bates, Andrew D., Nagaraja, Valakunja   +4 more
openaire   +2 more sources

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Direct observation of strand passage by DNA-topoisomerase and its limited processivity. [PDF]

PLoS ONE, 2012
Type-II DNA topoisomerases resolve DNA entanglements such as supercoils, knots and catenanes by passing one segment of DNA duplex through a transient enzyme-bridged double-stranded break in another segment.
Katsunori Yogo, Taisaku Ogawa, Masahito Hayashi, Yoshie Harada, Takayuki Nishizaka, Kazuhiko Kinosita   +5 more
doaj   +1 more source

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability [PDF]

, 2015
Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA
Anna L. Chambers, Hiasa, Jessica A. Downs, Jonathan Baxter, Sahar Mansoubi, Stephanie A. Schalbetter   +5 more
core   +3 more sources

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Kinetic pathways of topology simplification by Type-II topoisomerases in knotted supercoiled DNA

bioRxiv, 2018
The topological state of covalently closed, double-stranded DNA is defined by the knot type K and the linking-number difference ΔLk relative to unknotted relaxed DNA. DNA topoisomerases are essential enzymes that control the topology of DNA in all cells.
Riccardo Ziraldo, A. Hanke, S. Levene
semanticscholar   +1 more source

The causes and consequences of topological stress during DNA replication [PDF]

, 2016
The faithful replication of sister chromatids is essential for genomic integrity in every cell division. The replication machinery must overcome numerous difficulties in every round of replication, including DNA topological stress.
Andrea Keszthelyi, Champoux, Hiasa, Hiasa, Hiasa, Jonathan Baxter, Kornberg, Nicola Minchell   +7 more
core   +2 more sources