Results 131 to 140 of about 12,293 (210)

Delivery of nano‐formulated drugs to solid tumours is selectively increased by co‐application of the vascular disrupting agent CA4P

British Journal of Pharmacology, Volume 183, Issue 16, Page 4663-4674, August 2026.
Background and purpose Nano‐formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to selectively enhance tumour delivery are lacking.
Annabel Kitowski, Constanze Heise, Stefanie Sperling, Jasmin Hotz, Danica Bajic, Marina Rubey, Kathrin Klar, Georg Höfner, Julien Vollaire, Veronique Josserand, Jean‐Luc Coll, Oliver Thorn‐Seshold, Petar Marinković, Julia Thorn‐Seshold   +13 more
wiley   +1 more source

Experimental localization of metal-binding sites reveals the role of metal ions in type II DNA topoisomerases. [PDF]

Proc Natl Acad Sci U S A
Wang B, Najmudin S, Pan XS, Mykhaylyk V, Orr C, Wagner A, Govada L, Chayen NE, Fisher LM, Sanderson MR.   +9 more
europepmc   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, Volume 183, Issue 16, Page 4735-4760, August 2026.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Immunomodulatory Potential of Quinoline Q3, a Selective Inhibitor of the Canonical NF‐κB Pathway in Macrophages

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
The quinolone Q3 specifically enhances the DNA binding of the p50/p50 NF‐κB dimers, while inhibiting the activity of the p65 transcriptional activator, resulting in inhibition of the NF‐κB canonical pathway in lipopolysaccharide (LPS)‐stimulated macrophages.
Konstantinos Michail, Panagiotis Ntavaroukas, Vasiliki Petriki, Evangelos Tsioupros, Stella Manta, Barry J. Campbell, Stamatia Papoutsopoulou   +6 more
wiley   +1 more source

Novobiocin Susceptibility of MukBEF-Deficient Escherichia coli Is Combinatorial with Efflux and Resides in DNA Topoisomerases. [PDF]

Antimicrob Agents Chemother, 2016
Petrushenko ZM, Zhao H, Zgurskaya HI, Rybenkov VV.   +3 more
europepmc   +1 more source

DNA topoisomerases in cancer treatment [PDF]

BMJ, 1988
openaire   +2 more sources

The Roles of Topoisomerases in Transcriptional Regulation. [PDF]

Int J Mol Sci
Fenelon KD, Madabhushi R.
europepmc   +1 more source

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations. [PDF]

Sci Rep
El-Sayed ASA, Aboelez MO, Ezelarab HAA, Ewedah TM, El-Baz AF, Ashraf R, Diab A, Safwat G, Rady AM, El-Mekkawy RM.   +9 more
europepmc   +1 more source

Microbial Primer: Bacterial DNA supercoiling. [PDF]

Microbiology (Reading)
Dorman CJ.
europepmc   +1 more source

DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation. [PDF]

PLoS One, 2015
Roedgaard M, Fredsoe J, Pedersen JM, Bjergbaek L, Andersen AH.   +4 more
europepmc   +1 more source