Results 31 to 40 of about 12,293 (210)

Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

eLife, 2018
Type II topoisomerases manage DNA supercoiling and aid chromosome segregation using a complex, ATP-dependent duplex strand passage mechanism. Type IIB topoisomerases and their homologs support both archaeal/plant viability and meiotic recombination. Topo
Timothy J Wendorff, James M Berger
doaj   +1 more source

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Pharmaceuticals, 2023
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments.
Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie   +2 more
doaj   +1 more source

Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds

Pharmaceuticals, 2023
With the increasing need for effective compounds against cancer or pathogen-borne diseases, the development of new tools to investigate the enzymatic activity of biomarkers is necessary.
Josephine Geertsen Keller, Kamilla Vandsø Petersen, Karol Mizielinski, Celine Thiesen, Lotte Bjergbæk, Rosa M. Reguera, Yolanda Pérez-Pertejo, Rafael Balaña-Fouce, Angela Trejo, Carme Masdeu, Concepcion Alonso, Birgitta R. Knudsen, Cinzia Tesauro   +12 more
doaj   +1 more source

Anti-topoisomerase drugs as potent inducers of chromosomal aberrations

Genetics and Molecular Biology, 2000
DNA topoisomerases catalyze topological changes in DNA that are essential for normal cell cycle progression and therefore they are a preferential target for the development of anticancer drugs.
Loredana Bassi, Fabrizio Palitti
doaj   +1 more source

DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function

eLife, 2022
Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex.
Joshua Jeong, Joyce H Lee, Claudia C Carcamo, Matthew W Parker, James M Berger   +4 more
doaj   +1 more source

DNA binding and cleavage mechanism of DNA topoisomerase VI, an evolutionary counterpart of Spo11/Wadjet/Gabija systems [PDF]

Structural Dynamics
Type II topoisomerases resolve DNA supercoiling and chromosome entanglements. Type IIB topoisomerases, exemplified by Top6, are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 subunits ...
Daniel E Richman, Timothy J Wendorff, Fahad Rashid, Curtis Beck, Matthew L Baker, Jonathan M Fogg, Lynn Zechiedrich, James M Berger   +7 more
doaj   +1 more source

Our Evolving Understanding of the Mechanism of Quinolones

Antibiotics, 2018
The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled ...
Arnaud Gutierrez, Jonathan M. Stokes, Ivan Matic   +2 more
doaj   +1 more source

DNA topoisomerase inhibitors: biflavonoids from Ouratea species

Brazilian Journal of Medical and Biological Research, 2002
Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz- Filho, A. Echevarria   +6 more
doaj   +1 more source

Structural basis for allosteric regulation of Human Topoisomerase IIα

Nature Communications, 2021
Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing ...
Arnaud Vanden Broeck, Christophe Lotz, Robert Drillien, Léa Haas, Claire Bedez, Valérie Lamour   +5 more
doaj   +1 more source

Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

Cell Reports, 2021
Summary: Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation.
Andrés Herrero-Ruiz, Pedro Manuel Martínez-García, José Terrón-Bautista, Gonzalo Millán-Zambrano, Jenna Ariel Lieberman, Silvia Jimeno-González, Felipe Cortés-Ledesma   +6 more
doaj   +1 more source