Improvement and Replacement of Camptothecins in Cancer Therapy Due to the Decrease in their Selectivity and Efficiency [PDF]
, 2005 DNA replication, transcription, and chromosome condensation require enzymes that can regulate the topological changes occurring in DNA following these processes. Topoisomerases are such enzymes. These catalyze the cleavage of single-stranded DNA (ssDNA)
Kilian, Dorota
core +1 more source
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
Photochemistry and Photobiology, EarlyView.The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source
Nature Communications, 2018 Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. Here the authors provide evidence that in Drosophila, Topoisomerase 3β interacts biochemically and genetically with the RNAi-induced ...
Seung Kyu Lee +16 more
doaj +1 more source
Fluorescent Probes Detecting the Phagocytic Phase of Apoptosis: Enzyme-Substrate Complexes of Topoisomerase and DNA [PDF]
, 2011 Candace L. Minchew, Vladimir V. Didenko
openalex +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
Mutations in topoisomerase IIβ result in a B cell immunodeficiency
Nature Communications, 2019 Topoisomerases are required to release topological stress on DNA during replication and transcription. Here, Broderick et al. report genetic variants in TOP2B that cause a syndromic B cell immunodeficiency associated with reduced TOP2B function, defects ...
Lori Broderick +22 more
doaj +1 more source
RAP80 Acts Independently of BRCA1 in Repair of Topoisomerase II Poison-Induced DNA Damage [PDF]
, 2010 Junko Iijima +3 more
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Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
An Investigation into the Interaction of Various Salt Ions with DNA Topoisomerase IA during the Relaxation of Negatively-Supercoiled DNA. [PDF]
, 2007 Topoisomerases are enzymes that change the topological state of DNA by catalyzing the cleavage, subsequent strand passage and religation of either one or both strands of DNA during DNA replication and transcription.
Burdette, Eric
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Drug Development Research, Volume 87, Issue 2, April 2026.ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu +7 more
wiley +1 more source