Results 101 to 110 of about 2,307,592 (280)

Supercoiled DNA: Structure [PDF]

, 2015
Supercoiling is introduced into DNA molecules when the double helix is twisted around its own axis in three‐dimensional space. Experimental techniques that are sensitive to molecular shape can be used to analyse the topological states of DNA, but the ...
Bowater, Richard
core   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Unzipping DNA - towards the first step of replication

, 1999
The opening of the Y-fork - the first step of DNA replication - is shown to be a critical phenomenon under an external force at one of its ends. From the results of an equivalent delocalization in a non-hermitian quantum-mechanics problem we show the ...
Bhattacharjee, Somendra M.
core   +1 more source

Identification and characterization of the orf virus type I topoisomerase [PDF]

, 1995
Vaccinia virus (VV) and Shope fibroma virus (SFV), representatives of the orthopox and leporipox genera, respectively,encode type I DNA topoisomerases.
Nancy Klemperer, David J. Lyttle, Dominique Tauzin, Paula Traktman, Anthony J. Robinson, Bauer, Brill, Champoux, D'Arpa, DeLange, Fernandez-Beros, Fleming, Fleming, Fogelsong, Fraser, Goebel, Gupta, Higgins, Kim, Klemperer, Laemmu, Liu, Lynn, Mercer, Moore, Morham, Morham, Moss, Osheroff, Rigby, Rosel, Sanger, Schultz, Shaffer, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Studier, Thrash, Traktman, Traktman, Traktman, Uemura, Upton, Vogelstein, Wang, Wang   +51 more
core   +5 more sources

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Over-expression of Topoisomerase II Enhances Salt Stress Tolerance in Tobacco [PDF]

, 2016
Topoisomerases are unique enzymes having an ability to remove or add DNA supercoils and untangle the snarled DNA. They can cut, shuffle and religate DNA strands and remove the torsional stress during DNA replication, transcription or recombination events.
Badri N. Singh, Malireddy K. Reddy, Manchikatla V. Rajam, Riffat John, Sudhir K. Sopory, Tanushri Kaul, Uma Ganeshan   +6 more
core   +2 more sources

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Simian virus 40 DNA replication in vitro: identification of multiple stages of initiation [PDF]

, 1989
A cell-free DNA replication system dependent upon five purified cellular proteins, one crude cellular fraction, and the simian virus 40 (SV40)-encoded large tumor antigen (T antigen) initiated and completed replication of plasmids containing the SV40 ...
Tsurimoto, T., Fairman, M. P., Stillman, B.   +2 more
core   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms

Nucleic Acids Research, 2009
Topoisomerases are essential enzymes that solve topological problems arising from the double-helical structure of DNA. As a consequence, one should have naively expected to find homologous topoisomerases in all cellular organisms, dating back to their ...
P. Forterre, D. Gadelle
semanticscholar   +1 more source