Results 91 to 100 of about 1,469,390 (226)

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Untangling bacterial DNA topoisomerases functions

International audienceTopoisomerases are the main enzymes capable of resolving the topological constraints imposed by DNA transactions such as transcription or replication. All bacteria possess topoisomerases of different types.
Espéli, Olivier, Bruno, Lisa, Borde, Céline   +2 more
core   +1 more source

Two type I topoisomerases maintain DNA topology in human mitochondria

, 2022
Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated the subcellular localisation and activity of the six human topoisomerases with a
Erdinc, Direnis,, Deen, D., Pyle, Angela, Austin, C. A., Cowell, I. G., Chapman, James, Rodríguez-Luis, Alejandro, Menger, K. E., Khazeem, M. M., Casement, J. W., Austin, Caroline A, Cowell, Ian G, Di Leo, V., Nicholls, Thomas J, Díaz-Maldonado, Héctor, Deen, Dasha, Menger, Katja E, Nicholls, T. J., Casement, John W, Di Leo, Valeria, Chapman, J., Khazeem, Mushtaq M, Erdinc, Direnis, Falkenberg, Maria, Falkenberg, Maria,, Diaz-Maldonado, Hector,, Rodriguez-Luis, A., Pyle, A.   +27 more
core   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro

Frontiers in Pharmacology, 2017
DNA topoisomerases 1 and 2 are enzymes that maintain DNA topology and play important essential genome functions, including DNA replication and transcription.
Onat Kadioglu, Ariel Chan, Alena Cong Ling Qiu, Vincent Kam Wai Wong, Vanessa Colligs, Sabine Wecklein, Halima Freund-Henni Rached, Thomas Efferth, Wen-Luan Wendy Hsiao   +8 more
doaj   +1 more source

Targeting DNA topoisomerases: past & future. [PDF]

Cancer Drug Resist, 2021
Gmeiner WH, van Waardenburg RCAM.
europepmc   +1 more source

E. coli DNA topoisomerases.

, 2019
E. coli DNA topoisomerases.
Zhong Qian (8119712), Subhash C. Verma (8119709), Sankar L. Adhya (8119715)   +2 more
core   +1 more source

What's on the Other Side of the Gate: A Structural Perspective on DNA Gate Opening of Type IA and IIA DNA Topoisomerases. [PDF]

Int J Mol Sci, 2023
Vidmar V, Vayssières M, Lamour V.
europepmc   +1 more source

New Insights into the Geometry and Topology of DNA Replication Intermediates

Biology
The regulation of superhelical stress, mediated by the combined action of topoisomerases and fork rotation, is crucial for DNA replication. The conformational changes during DNA replication are still experimentally challenging, mainly due to the rapid ...
Victor Martínez, Edith Ruiz-Díaz, Delia Cardozo, Cristian Cappo, Christian E. Schaerer, Jorge Cebrián, Dora B. Krimer, María José Fernández-Nestosa   +7 more
doaj   +1 more source

Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells

, 2012
DNA topoisomerases are nuclear enzymes that are the targets for several anticancer drugs. In this study we investigated the antiproliferative activity against human leukaemia cell lines and the effects on topoisomerase I and II of evodiamine, which is a ...
Hartley, J.A., Hartley, J.M., White, K.N., Pan, X., Wang, Z., Bligh, S.W.A.   +5 more
core   +1 more source