Results 71 to 80 of about 2,307,592 (280)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer

Антибиотики и Химиотерапия, 2020
Topoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an ...
A. A. Samuseva, R. V. Lyubota, A. S. Zotov, R. I. Vereshchako   +3 more
doaj  

Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cancer is a major health issue adsorbing the attention of a biomedical research. To fight this disease, new drugs are developed, specifically tailored to target biological pathways or peculiar components of the tumour cells.
Valeria Visone, Ildikó Szabó, Giuseppe Perugino, Ferenc Hudecz, Zoltán Bánóczi, Anna Valenti   +5 more
doaj   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

“Breaking up is hard to do”: the formation and resolution of sister chromatid intertwines [PDF]

, 2014
The absolute necessity to resolve every intertwine between the two strands of the DNA double helix provides a massive challenge to the cellular processes that duplicate and segregate chromosomes.
Bartkova, Baumann, Baxter, Baxter, Baxter, Bermejo, Bester, Branzei, Branzei, Brill, Burrell, Bzymek, Cejka, Champoux, Champoux, Chan, Chan, Chang, Chu, Crisona, Cuylen, Cuylen, Delbrück, Di Micco, Dominguez-Sola, Ekholm-Reed, Farcas, Fernandez, Gandhi, Gangloff, Gerlich, Germann, Giet, Goodwin, Gorgoulis, Halazonetis, Hardy, Hawkins, Hendzel, Hiasa, Hiasa, Hiasa, Hills, Hirano, Hirano, Hirano, Holm, Hsu, Jonathan Baxter, Kato, Kato, Khodursky, Khodursky, Kimura, Kimura, Kitamura, Koshland, Kreuzer, Kueng, Lavoie, Leman, Lucas, Mantiero, Maresca, Marston, Martinez-Robles, Matos, McClendon, McClintock, McGlynn, McGuffee, Mullen, Naughton, Neelsen, Newport, Oliveira, Ono, Paulson, Peter, Postow, Rattner, Rybenkov, Rybenkov, Sakaguchi, Samejima, Schoeffler, Schvartzman, Shamu, Shintomi, Spruck, Stuchinskaya, Sullivan, Sundin, Sundin, Suski, Symington, Szakal, Tedeschi, Temime-Smaali, Toledo, Vologodskii, Vos, Wang, Wang, Wang, Watson, Watson, Wei, Wilkins, Zechiedrich, Zechiedrich   +110 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]

, 2016
Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Aedo, Afonine, Amundsen, Amundsen, Bannister, Baños-Sanz, Cano, Cirz, CLSI, Cole, Court, Court, Cronan, Darrigo, Datta, Dillingham, Emsley, Forage, González-Soltero, Henderson, Kennaway, Kulkarni, Li, Liu, Liu, López, McDaniel, Murphy, Murphy, Murphy, Muyrers, Paczosa, Pettersen, Robinson, Sakaki, Scheres, Singleton, Tamae, Urnavicius, Wang, Wiegand, Wigley, Wilkinson, Zhang, Zhang   +44 more
core   +5 more sources

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions [version 1; peer review: 3 approved]

F1000Research, 2019
DNA topoisomerases are enzymes that catalyze changes in the torsional and flexural strain of DNA molecules. Earlier studies implicated these enzymes in a variety of processes in both prokaryotes and eukaryotes, including DNA replication, transcription ...
Mary-Ann Bjornsti, Scott H. Kaufmann
doaj   +1 more source

Topological and geometrical entanglement in a model of circular DNA undergoing denaturation

, 2002
The linking number (topological entanglement) and the writhe (geometrical entanglement) of a model of circular double stranded DNA undergoing a thermal denaturation transition are investigated by Monte Carlo simulations. By allowing the linking number to
Baiesi, M., Orlandini, E., Stella, A. L.
core   +1 more source