Results 121 to 130 of about 1,469,390 (226)

MYC modulates TOP2A diffusion to promote substrate detection and activity

Nature Communications
Topoisomerases alleviate DNA supercoiling by cleaving and resealing DNA strands. Previously, we showed that the oncoprotein MYC recruits and stimulates topoisomerases to remove DNA entanglements generated by oncogenic transcription.
Donald P. Cameron, Kathryn Jackson, Alessia Loffreda, Carl Möller, Vladislav Kuzin, Matteo Mazzocca, Evanthia Iliopoulou, Hallgerdur Kolbeinsdottir, Andrej Paluda, Evgeniya Pavlova, Bea Jagodic, Brian Saidel Lopez Duran, Valérie Lamour, Fredrik Westerlund, Davide Mazza, Laura Baranello   +15 more
doaj   +1 more source

Local selection rules that can determine specific pathways of DNA unknotting by type II DNA topoisomerases [PDF]

, 2017
We performed numerical simulations of DNA chains to understand how local geometry of juxtaposed segments in knotted DNA molecules can guide type II DNA topoisomerases to perform very efficient relaxation of DNA knots.
Weber, Cedric, Flammini, Alessandro, Burnier, Yannis, Stasiak, Andrzej   +3 more
core  

Discovery of edodine, a natural compound from Lentinula edodes with antibacterial activity for the biological control of fire blight pathogen Erwinia amylovora

Pest Management Science, EarlyView.
Novel edodine was identified from Lentinula edodes HK761, exhibiting biocontrol potential against fire blight by affecting motility, intracellular ATP level, and cell division of Erwinia amylovora. Abstract BACKGROUND In the search for biological resources with antibacterial activity against Erwinia amylovora, the culture filtrate of Lentinula edodes ...
Yeong Seok Kim, Jae Woo Han, Bomin Kim, Chunggeon Lee, Daeui Park, Jaehyuk Choi, Gyung Ja Choi, Hun Kim   +7 more
wiley   +1 more source

Strain‐specific monitoring of Bacillus amyloliquefaciens AH2 in strawberry fields using a specific molecular marker

Pest Management Science, EarlyView.
A novel strain‐specific TaqMan quantitative polymerase chain reaction assay targeting the hsdM gene was developed to monitor Bacillus amyloliquefaciens AH2 in strawberries, providing a foundational tool to optimize biocontrol management. Abstract BACKGROUND The biocontrol agent Bacillus amyloliquefaciens AH2 is effective against Botrytis cinerea in ...
M Mercedes Maldonado‐González, Julio Rodríguez‐Romero, Jonatan C Campillo‐Brocal, Pedro R Molina‐Guevara, María Sánchez‐García, Laura Martínez‐Pozuelo, Antonio Bernal‐Soro, María A Ayllón   +7 more
wiley   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis

Journal of Mazandaran University of Medical Sciences, 2020
Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies.
Elham Kialashaki, Mahdi Fakhar, Javad Akhtari, Roghiyeh Faridnia, Masoud Keighobadi   +4 more
doaj  

Harnessing the Folding of Antitumor Peptides for Controlled Carrier‐Free Drug Delivery

Small, EarlyView.
A disulfide‐bridged stapled p53 α‐helix co‐assembled with doxorubicin into protease‐resistant nanocomplexes. Reductive intracellular conditions induced helix refolding and nanostructure disassembly, which enabled the coordinated release of the chemotherapeutic agent and anticancer peptide.
Jae Yun Lee, Moo Chang Park, Sung Chan Choi, Jieun Kim, Joo‐young Kim, Jiah Lee, Hyun Jin Kim, Kyobum Kim, Yongju Kim, Woo‐jin Jeong   +9 more
wiley   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy

Smart Molecules, EarlyView.
A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song, Hui Bian, Lei Liu, Gahyeon Park, Bingqing Sun, Qiongzheng Hu, Juyoung Yoon   +6 more
wiley   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source