Results 61 to 70 of about 1,464,924 (278)

Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors

Angewandte Chemie, EarlyView.
A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma, Erika McCarthy, N. Sanjeeva Murthy, Cameron McGovern, Zhenyu Han, Şölen Ekesan, Subhajit Nandi, Advik Sirimarapu, Wilma K. Olson, Darrin M. York, Yuwei Gu   +10 more
wiley   +2 more sources

DNA topology: Topoisomerases keep it simple [PDF]

, 1997
The ability of type II DNA topoisomerases to perturb the equilibrium distributions of DNA topoisomers is a consequence of their ability to hydrolyse ATP.
Bates, Andrew D, Maxwell, Anthony
core   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, EarlyView.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

A role for topoisomerase II alpha in chromosome damage in human cell lines [PDF]

, 2010
Human response to ionising radiation (IR) shows a wide variation. This is most clearly seen in the radiation-response of cells as measured by frequencies of chromosomal aberrations.
Terry, Samantha Y.A.
core   +2 more sources

Supercoiled DNA recognition and cleavage control in topoisomerase VI

Nature Communications
Type II topoisomerases modulate DNA supercoiling and resolve chromosome entanglements. Type IIB topoisomerases, exemplified by DNA topoisomerase VI (Top6), are used by plants and archaea to support endoreduplication and cell proliferation, respectively ...
Daniel E. Richman, Timothy J. Wendorff, Fahad Rashid, Curtis Beck, Qianyun Yan, Haley R. Johnson, Ryan A. Eckerty, Jonathan M. Fogg, Matthew L. Baker, Lynn Zechiedrich, James M. Berger   +10 more
doaj   +1 more source

Clinical Significance of Expression of Topoisomerase 2а in Breast Cancer

Антибиотики и Химиотерапия, 2020
Topoisomerases are enzymes that control the topology of DNA. Topoisomerases are divided into types 1 and 2, depending on the mechanism of action. The article discusses the structure and mechanisms of the action of topoisomerases, the possibility of an ...
A. A. Samuseva, R. V. Lyubota, A. S. Zotov, R. I. Vereshchako   +3 more
doaj  

Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cancer is a major health issue adsorbing the attention of a biomedical research. To fight this disease, new drugs are developed, specifically tailored to target biological pathways or peculiar components of the tumour cells.
Valeria Visone, Ildikó Szabó, Giuseppe Perugino, Ferenc Hudecz, Zoltán Bánóczi, Anna Valenti   +5 more
doaj   +1 more source

Tightening of DNA knots by supercoiling facilitates their unknotting by type II DNA topoisomerases [PDF]

, 2011
Using numerical simulations, we compare properties of knotted DNA molecules that are either torsionally relaxed or supercoiled. We observe that DNA supercoiling tightens knotted portions of DNA molecules and accentuates the difference in curvature ...
Giovanni Dietler, Witz, G., Andrzej Stasiak, Dietler, G., Guillaume Witz, Stasiak, A.   +5 more
core   +2 more sources

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

DNA topoisomerases as targets for anticancer drugs

, 2001
DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Topcu, Z
core   +1 more source