Results 81 to 90 of about 1,464,924 (278)
Advanced Science, EarlyView.TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu +7 more
wiley +1 more source
Mechanism of topology simplification by type II DNA topoisomerases [PDF]
, 2001 Type II DNA topoisomerases actively reduce the fractions of knotted and catenated circular DNA below thermodynamic equilibrium values. To explain this surprising finding, we designed a model in which topoisomerases introduce a sharp bend in DNA.
Cozzarelli, N. R. +6 more
core +1 more source
Advanced Science, EarlyView.In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang +20 more
wiley +1 more source
PLoS ONE, 2013 DNA topoisomerases are highly exploited targets for antimicrobial drugs. The spread of antibiotic resistance represents a significant threat to public health and necessitates the discovery of inhibitors that target topoisomerases in novel ways.
James A Taylor +4 more
doaj +1 more source
Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie
Angewandte Chemie, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Structural insights into the DNA topoisomerase II of the African swine fever virus
Nature CommunicationsType II topoisomerases are ubiquitous enzymes that play a pivotal role in modulating the topological configuration of double-stranded DNA. These topoisomerases are required for DNA metabolism and have been extensively studied in both prokaryotic and ...
Jingyuan Cong +8 more
doaj +1 more source
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate
Nature Communications, 2018 Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-
Shin-Fu Chen +7 more
doaj +1 more source
The Molecular Perspective: DNA Topoisomerases [PDF]
STEM CELLS, 2002 Abstract Learning Objectives After completing this course, the reader will be able to: Gain a basic understanding of the structure and function of the DNA topoisomerases and their place as targets for chemotherapy. Access and take the CME test online and receive one
openaire +3 more sources
Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Can DNA Topoisomerases Be Ribonucleases? [PDF]
Cell, 1997 DNA topoisomerases catalyze changes in the linkage of DNA strands through a concerted mechanism of DNA strand cleavage and ligation reactions (for review, seeWang 1996xWang, J.C. Annu. Rev. Biochem. 1996; 65: 635–692Crossref | PubMedSee all ReferencesWang 1996).
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